Page 1.1
1 15 16 30 31 45 46 60 61 75 76 90
1 SKH --------------- AKYDIKALIGRGSFS RVVRVEHRATRQPYA IKMIETK----YREG REVCES-ELRVLRRV R-HANIIQLVEVFE- 68
2 APK --------------- DQFERIKTLGTGSFG RVMLVKHMETGNHYA MKILDKQKV-VKLKQ IEHTLN-EKRILQAV N-FPFLVKLEFSFK- 71
3 D28 --------------- ANYKRLEKVGEGTYG VVYKALDLRPGQGQR VVALKKIRLESEDEG VPSTAIREISLLKEL K-DDNIVRLYDIVHS 74
4 EE1 --------------- TRFRNVTLLGSGEFS EVFQVEDPVEKTLKY AVKKLKVK--FSGPK ERNRLLQEVSIQRAL KGHDHIVELMDSWEH 73
5 AF1 --------------- SEVMLSTRIGSGSFG TVYKGKWHGDVAVKI LKVVDPTP-----EQ FQAFRN-EVAVLRKT R---HVNILLFMGYM 66
6 GFR --------------- TEFKKIKVLGSGAFG TVYKGLWIPEGEKVK IPVAIKELREATSPK ANKEILDEAYVMASV DN-PHVCRLLGICLT 74
7 FES VLNRAVPKDKWVLNH EDLVLGEQIGRGNFG EVFSGRLRADNTLVA VKSCRETLP----PD IKAKFLQEAKILKQY S-HPNIVRLIGVCT- 84
8 DGM --------------- DQLVLGRTLGSGAFG QVVEATAHGLSHSQA TMKVAVKMLKSTARS SEKQALMSELYGDLV DYLHRNKHTFLQRHS 75
9 MOS --------------- EQVCLLQRLGAGGFG SVYKATYRGVPVAIK QVNKCTKN-----RL ASRRSFWAELNVARL R-HDNIVRVVAASTR 69
10 SVK --------------- MGFTIHGALTPGSEG CVFDSSHPDYPQRVI VKAGWYTS------- ----TSHEARLLRRL D-HPAILPLLDLHVV 63
Page 2.1
91 105 106 120 121 135 136 150 151 165 166 180
1 SKH --------------- --------------- ----------TQERV YMVMELATGGELFDR IIAKG--S------- --------------- 94
2 APK --------------- --------------- ----------DNSNL YMVMEYVPGGEMFSH LRRIG--R------- --------------- 97
3 D28 --------------- --------------- ----------DAHKL YLVFEFLDLDLKRYM EGIPKDQP------- --------------- 102
4 EE1 --------------- --------------- ----------GGFLY MQVELCENGSLDRFL EEQGQLSR------- --------------- 101
5 AF1 --------------- --------------- ----------TKDNL AIVTQWCEGSSLYKH LHVQET-K------- --------------- 93
6 GFR --------------- --------------- ----------STVQL ITQLMPFGCLLDYVR EHKDN---------- --------------- 99
7 FES --------------- --------------- ----------QKQPI YIVMELVQGGDFLTF LRTEG-AR------- --------------- 111
8 DGM NKHCPPSAELYSNAL PVGFSLPSHLNLTGE SDGGYMDMSKDESID YVPMLDMKGDIKYAD IESPSYMAPYDNYVP SAPERTYRATLINDS 165
9 MOS --------------- --------------- -------TPAGSNSL GTIIMEFGGNVTLHQ VIYGAAGHPEGDAG- --------EPHCRTG 113
10 SVK S-------------- --------------- -----------GVTC LVLPKYQADLYTYLS RRLNP---------- --------------- 88
Page 3.1
181 195 196 210 211 225 226 240 241 255 256 270
1 SKH --FTERDATRVLQMV LDGVRYLHALGITHR DLKPENLLYYHPGTD SKIIITDFGLASARK KGDDC--LMKTTCGT PEYIAPEVLVR---K 177
2 APK --FSEPHARFYAAQI VLTFEYLHSLDLIYR DLKPENLLIDQQG-- -YIQVTDFGFAKR-V KG-----RTWTLCGT PEYLAPEIILS---K 173
3 D28 --LGADIVKKFMMQL CKGIAYCHSHRILHR DLKPQNLLINKDG-- -NLKLGDFGLARAFG VPLR---AYTHEIVT LWYRAPEVLLGG--K 182
4 EE1 --LDEFRVWKILVEV ALGLQFIHHKNYVHL DLKPANVMITFEG-- -TLKIGDFGMASVWP VP-----RGMEREGD CEYIAPEVLAN---H 178
5 AF1 --FQMFQLIDIARQT AQGMDYLHAKNIIHR DMK-SNNIFLHEG-- LTVKIGDFGLATVKS RWSGSQ-QVEQPTGS VLWMAPEVIRMQDNN 177
6 GFR --IGSQYLLNWCVQI AKGMNYLEDRRLVHR DLAARNVLVKTPQ-- -HVKITDFGLAKLLG AEEKEY-HAEGGKVP IKWMALESILH---R 180
7 FES --LRMKTLLQMVGDA AAGMEYLESKCCIHR DLAARNCLVTEKN-- -VLKISDFGMSREAA DGIYAA-SGGLRQVP VKWTAPEALNYG--- 192
8 DGM PVLSYTDLVGFSYQV ANGMDFLASKNCVHR DLAARNVLICEGK-- -LVKICDFGLARDIM RDSNYI-SKGSTYLP LKWMAPESIFN---S 248
9 MOS GQLSLGKCLKYSLDV VNGLLFLHSQSIVHL DLKPANILISEQD-- -VCKISDFGCSEKLE DLLCFQTPSYPLGGT YTHRAPELLKG---E 197
10 SVK --LGRPQIAAVSRQL LSAVDYIHRQGIIHR DIKTENIFINTPE-- -DICLGDFGAACFVQ GSRSSP-FPYGIAGT IDTNAPEVLAG---D 169
Page 4.1
271 285 286 300 301 315 316 330 331 345 346 360
1 SKH PYTNSVDMWALGVIA YILLSGTMPFEDDNR T-------RLYRQIL RGKYSYSGEPWPSVS NL------------- ------------AKD 235
2 APK GYNKAVDWWALGVLI YEMAAGYPPFFADQP I-------QIYEKIV SGKVRFPSHFSSDLK DL------------- ------------LRN 231
3 D28 QYSTGVDTWSIGCIF AEMCNRKPIFSGDSE I-------DQIFKIF RVLGTPNEAIWPDIV YLPDFKPSFPQWRRK DLSQVVPSLDPRGID 265
4 EE1 LYDKPADIFSLGITV FEAAANIVLPDNGQS W-------QKLRSGD LSDAPRLSSTDNGSS LTSSSRETPAN---- -----SIIGQGGLDR 252
5 AF1 PFSFQSDVYSYGIVL YELMTGELPYSRDQI I-------FMVGRGY ASPDLSKLYKNCPKA MK------------- --------------R 233
6 GFR IYTHQSDVWSYGVTV WELMTFGSKPYDGIP A-------SEISSIL EKGERLPQPPICTID VY------------- --------------M 236
7 FES RYSSESDVWSFGILL WETFSLGASPYPNLS N-------QQTREFV EKGGRLPCPELCPDA VF------------- --------------R 248
8 DGM LYTTLSDVWSFGILL WEIFTLGGTPYPELP MN------DQFYNAI KRGYRMAQPAHASDE IY------------- --------------E 305
9 MOS GVTPKADIYSFAITL WQMTTKQAPYSGERQ HI------LYAVVAY DLRPSLSAAVFEDSL PGQ------------ -----------RLGD 258
10 SVK PYTTTVDIWSAGLVI FETAVHNASLFSAPR GPKRGPCDSQITRII RQAQVHVDEFSPHPE SR------------- --------------L 232
Page 5.1
361 375 376 390 391 405 406 420 421 435 436 450
1 SKH FIDRLLTVDPGARMT ALQALRHPWVVSM-- ----- 263
2 APK LLQVDLTKRFGNLKD GVNDIKNHK------ ----- 255
3 D28 LLDKLLAYDPINRIS ARRAAIHPYFQES-- ----- 293
4 EE1 VVEWMLSPEPRNRPT IDQILATDEVCWV-- ----- 280
5 AF1 LVADCVKKVKEERPL FPQILSSIELLQH-- ----- 261
6 GFR IMVKCWMIDADSRPK FRELIIEFSKMAR-- ----- 264
7 FES LMEQCWAYEPGQRPS FSAIYQEL------- ----- 271
8 DGM IMQKCWEEKFETRPP FSQLVLLLERLLGEG YKKKY 340
9 MOS VIQRCWRPSAAQRPS ARLLLVDLTSLKA-- ----- 286
10 SVK TSRYRSRAAGNNRPP YTRPAWTRYYKMDID V---- 263
>SKH ---------------AKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIE TK----YREGREVCES-ELRVLRRVR-HANIIQLVEVFE----------- ------------------------------TQERVYMVMELATGGELFDR IIAKG--S------------------------FTERDATRVLQMVLDGVR YLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDC--LMK TTCGTPEYIAPEVLVR---KPYTNSVDMWALGVIAYILLSGTMPFEDDNR T-------RLYRQILRGKYSYSGEPWPSVSNL------------------ -------AKDFIDRLLTVDPGARMTALQALRHPWVVSM------- >APK ---------------DQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILD KQKV-VKLKQIEHTLN-EKRILQAVN-FPFLVKLEFSFK----------- ------------------------------DNSNLYMVMEYVPGGEMFSH LRRIG--R------------------------FSEPHARFYAAQIVLTFE YLHSLDLIYRDLKPENLLIDQQG---YIQVTDFGFAKR-VKG-----RTW TLCGTPEYLAPEIILS---KGYNKAVDWWALGVLIYEMAAGYPPFFADQP I-------QIYEKIVSGKVRFPSHFSSDLKDL------------------ -------LRNLLQVDLTKRFGNLKDGVNDIKNHK----------- >D28 ---------------ANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALK KIRLESEDEGVPSTAIREISLLKELK-DDNIVRLYDIVHS---------- ------------------------------DAHKLYLVFEFLDLDLKRYM EGIPKDQP------------------------LGADIVKKFMMQLCKGIA YCHSHRILHRDLKPQNLLINKDG---NLKLGDFGLARAFGVPLR---AYT HEIVTLWYRAPEVLLGG--KQYSTGVDTWSIGCIFAEMCNRKPIFSGDSE I-------DQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQV VPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES------- >EE1 ---------------TRFRNVTLLGSGEFSEVFQVEDPVEKTLKYAVKKL KVK--FSGPKERNRLLQEVSIQRALKGHDHIVELMDSWEH---------- ------------------------------GGFLYMQVELCENGSLDRFL EEQGQLSR------------------------LDEFRVWKILVEVALGLQ FIHHKNYVHLDLKPANVMITFEG---TLKIGDFGMASVWPVP-----RGM EREGDCEYIAPEVLAN---HLYDKPADIFSLGITVFEAAANIVLPDNGQS W-------QKLRSGDLSDAPRLSSTDNGSSLTSSSRETPAN--------- SIIGQGGLDRVVEWMLSPEPRNRPTIDQILATDEVCWV------- >AF1 ---------------SEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVD PTP-----EQFQAFRN-EVAVLRKTR---HVNILLFMGYM---------- ------------------------------TKDNLAIVTQWCEGSSLYKH LHVQET-K------------------------FQMFQLIDIARQTAQGMD YLHAKNIIHRDMK-SNNIFLHEG--LTVKIGDFGLATVKSRWSGSQ-QVE QPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSRDQI I-------FMVGRGYASPDLSKLYKNCPKAMK------------------ ---------RLVADCVKKVKEERPLFPQILSSIELLQH------- >GFR ---------------TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAI KELREATSPKANKEILDEAYVMASVDN-PHVCRLLGICLT---------- ------------------------------STVQLITQLMPFGCLLDYVR EHKDN---------------------------IGSQYLLNWCVQIAKGMN YLEDRRLVHRDLAARNVLVKTPQ---HVKITDFGLAKLLGAEEKEY-HAE GGKVPIKWMALESILH---RIYTHQSDVWSYGVTVWELMTFGSKPYDGIP A-------SEISSILEKGERLPQPPICTIDVY------------------ ---------MIMVKCWMIDADSRPKFRELIIEFSKMAR------- >FES VLNRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR ETLP----PDIKAKFLQEAKILKQYS-HPNIVRLIGVCT----------- ------------------------------QKQPIYIVMELVQGGDFLTF LRTEG-AR------------------------LRMKTLLQMVGDAAAGME YLESKCCIHRDLAARNCLVTEKN---VLKISDFGMSREAADGIYAA-SGG LRQVPVKWTAPEALNYG---RYSSESDVWSFGILLWETFSLGASPYPNLS N-------QQTREFVEKGGRLPCPELCPDAVF------------------ ---------RLMEQCWAYEPGQRPSFSAIYQEL------------ >DGM ---------------DQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVA VKMLKSTARSSEKQALMSELYGDLVDYLHRNKHTFLQRHSNKHCPPSAEL YSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYAD IESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMD FLASKNCVHRDLAARNVLICEGK---LVKICDFGLARDIMRDSNYI-SKG STYLPLKWMAPESIFN---SLYTTLSDVWSFGILLWEIFTLGGTPYPELP MN------DQFYNAIKRGYRMAQPAHASDEIY------------------ ---------EIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKY >MOS ---------------EQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKC TKN-----RLASRRSFWAELNVARLR-HDNIVRVVAASTR---------- ---------------------------TPAGSNSLGTIIMEFGGNVTLHQ VIYGAAGHPEGDAG---------EPHCRTGGQLSLGKCLKYSLDVVNGLL FLHSQSIVHLDLKPANILISEQD---VCKISDFGCSEKLEDLLCFQTPSY PLGGTYTHRAPELLKG---EGVTPKADIYSFAITLWQMTTKQAPYSGERQ HI------LYAVVAYDLRPSLSAAVFEDSLPGQ----------------- ------RLGDVIQRCWRPSAAQRPSARLLLVDLTSLKA------- >SVK ---------------MGFTIHGALTPGSEGCVFDSSHPDYPQRVIVKAGW YTS-----------TSHEARLLRRLD-HPAILPLLDLHVVS--------- -------------------------------GVTCLVLPKYQADLYTYLS RRLNP---------------------------LGRPQIAAVSRQLLSAVD YIHRQGIIHRDIKTENIFINTPE---DICLGDFGAACFVQGSRSSP-FPY GIAGTIDTNAPEVLAG---DPYTTTVDIWSAGLVIFETAVHNASLFSAPR GPKRGPCDSQITRIIRQAQVHVDEFSPHPESR------------------ ---------LTSRYRSRAAGNNRPPYTRPAWTRYYKMDIDV---- |