CLUSTAL W (1.83) multiple sequence alignment FORMAT by SPEM 1.0 # of seqs: 10 Alignment length: 426 D28 ---------------ANYKRLEKVGEGTYGVVYKALDLR-----PGQGQRVVALKKIRLE SKH ---------------AKYDIKALIGRGSFSRVVRVEHRA-----TRQ---PYAIKMIETK APK ---------------DQFERIKTLGTGSFGRVMLVKHME-----TGN---HYAMKILDKQ EE1 ---------------TRFRNVTLLGSGEFSEVFQVEDPV-----EKT--LKYAVKKLKVK GFR ---------------TEFKKIKVLGSGAFGTVYKGLWIPEGE-KVKI---PVAIKELREA DGM ---------------DQLVLGRTLGSGAFGQVVEATAHGLSHSQATM---KVAVKMLKST FES VLNRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRA-----DNT---LVAVKSCRET AF1 ---------------SEVMLSTRIGSGSFGTVYKGKWHG-----------DVAVKILKVV MOS ---------------EQVCLLQRLGAGGFGSVYKATYR-------GV---PVAIKQVNKC SVK ---------------MGFTIHGALTPGSEGCVFDSSHPD-----YPQ---RVIVKAG--- :. * :. * .. * D28 SE-D-EGVPSTAIREISLLKEL-K-DDNIVRLYDIVHSDAH----------KLYLVFE-- SKH YR----EGREVCESELRVLRRV-R-HANIIQLVEVFETQ-E----------RVYMVME-- APK KVVK-LKQIEHTLNEKRILQAV-N-FPFLVKLEFSFKDN-S----------NLYMVME-- EE1 FS-G-PKERNRLLQEVSIQRAL-KGHDHIVELMDSWEHG-G----------FLYMQVE-- GFR T--S-PKANKEILDEAYVMASV-D-NPHVCRLLGICLTS-T-----------VQLITQ-- DGM A--R-SSEKQALMSELYGDLVDYL-HRNKHTFLQRHSNK-HCPPSAELYSNALPVGFSLP FES L--P-PDIKAKFLQEAKILKQY-S-HPNIVRLIGVCTQK-Q----------PIYIVME-- AF1 DP-T-PEQFQAFRNEVAVLRKT-R-HVNILLFMGYMTKD-N-----------LAIVTQ-- MOS TK-NRLASRRSFWAELNVARL--R-HDNIVRVVAASTRT-PAG-----SNSLGTIIME-- SVK -------WYTSTSHEARLLRRL-D-HPAILPLLDLHVVS-G----------VTCLVLP-- * : D28 -----------------------FLDL-DLKRYMEGIPK--------------------- SKH -----------------------LATGGELFDRIIA------------------------ APK -----------------------YVPGGEMFSHLRR------------------------ EE1 -----------------------LCENGSLDRFLEEQGQ--------------------- GFR -----------------------LMPFGCLLDYVREH----------------------- DGM SHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTY FES -----------------------LVQGGDFLTFLRTE----------------------- AF1 -----------------------WCEGSSLYKHLHVQ----------------------- MOS -----------------------FGGNVTLHQVIYGAAGHPEGDAGEPHCR--------- SVK -----------------------KYQ-ADLYTYLSRR----------------------- : D28 -------DQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLI---NKDGNLKLGD SKH -------KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITD APK -------IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI---DQQGYIQVTD EE1 -------LSRLDEFRVWKILVEVALGLQFIHHKNYVHLDLKPANVMI---TFEGTLKIGD GFR -------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV---KTPQHVKITD DGM RATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLI---CEGKLVKICD FES -------GARLRMKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLV---TEKNVLKISD AF1 -------ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL---HEGLTVKIGD MOS ------TGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILI---SEQDVCKISD SVK -------LNPLGRPQIAAVSRQLLSAVDYIHRQGIIHRDIKTENIFI---NTPEDICLGD : : .:: ..*:. * : : * D28 FGLARAFGVPLR-AYTH-E--IVTLWYRAPEVLLGGK---QYSTGVDTWSIGCIFAEMCN SKH FGLASARKKGDD-CLMK-TT-CGTPEYIAPEVLVR-K---PYTNSVDMWALGVIAYILLS APK FGFAKRVKGR-----TW-TL-CGTPEYLAPEIILS-K---GYNKAVDWWALGVLIYEMAA EE1 FGMASVWPVP----RGM-ER-EGDCEYIAPEVLAN-H---LYDKPADIFSLGITVFEAAA GFR FGLAKLLGAEEK-EYHAEGG-KVPIKWMALESILH-R---IYTHQSDVWSYGVTVWELMT DGM FGLARDIMRDSN-YISKGST-YLPLKWMAPESIFN-S---LYTTLSDVWSFGILLWEIFT FES FGMSREAADGIY-AASGGLR-QVPVKWTAPEALNY-G---RYSSESDVWSFGILLWETFS AF1 FGLATVKSRWSG-SQQVEQP-TGSVLWMAPEVIRM-QDNNPFSFQSDVYSYGIVLYELMT MOS FGCSEKLEDLLC-FQTPSYPLGGTYTHRAPELLKG-E---GVTPKADIYSFAITLWQMTT SVK FGAACFVQGSRSSPFPY-GI-AGTIDTNAPEVLAG-D---PYTTTVDIWSAGLVIFETAV ** . : *.* . : :* :. . : D28 -R-KPIFSGD--------S-EIDQIFKIFRVLGTPNEAIWPDIVYLPDFK--PSFPQWRR SKH -G-TMPFEDD--------N-RTRLYRQILR--GK--------------Y----SYSGE-- APK -G-YPPFFAD--------Q-PIQIYEKIVS--GK--------------------VRFP-- EE1 -NIVLPDNGQ--------S-WQKLRSGDLS--DAPRLSSTDNGSSLTSSS--RETPA--- GFR FG-SKPYDGI--------P-ASEISSILEK--G---------------ER----LPQP-- DGM LG-GTPYPEL--------PMNDQFYNAIKR--G---------------YR----MAQP-- FES LG-ASPYPNL--------S-NQQTREFVEK--G---------------GR----LPCP-- AF1 -G-ELPYSRD--------Q----IIFMVGR--G---------------YASPDLSKLY-- MOS -K-QAPYSGE--------R-QHILYAVVAY--D---------------LR----PSLS-- SVK -H-NASLFSAPRGPKRGPC-DSQITRIIRQ--AQ--------------------VHVD-- : : D28 KDLSQVVPS------LDPRGIDLLDKLLAYDP-INR-----ISARRAAIHPYFQES---- SKH -P----WPS------VSNLAKDFIDRLLTVDP-GAR-----MTALQALRHPWVVSM---- APK -------SH------FSSDLKDLLRNLLQVDL-TKRFGNLKDGVNDIKNHK--------- EE1 -N----SII------GQGGLDRVVEWMLSPEP-RNR-----PTIDQILATDEVCWV---- GFR -------PI------CTIDVYMIMVKCWMIDA-DSR-----PKFRELIIE--FSKMAR-- DGM -------AH------ASDEIYEIMQKCWEEKF-ETR-----PPFSQLVLL--LERLLGEG FES -------EL------CPDAVFRLMEQCWAYEP-GQR-----PSFSAIYQE--L------- AF1 -------KN------CPKAMKRLVADCVKKVK-EER-----PLFPQILSS--IELLQH-- MOS -------AAVFEDSLPGQRLGDVIQRCWRPSA-AQR-----PSARLLLVD--LTSLKA-- SVK -------EF------SPHPESRLTSRYRSRAAGNNR-----PPYTRP-AW--TRYYKM-- * D28 ------ SKH ------ APK ------ EE1 ------ GFR ------ DGM YKK-KY FES ------ AF1 ------ MOS ------ SVK --DIDV