APK(62-203) D28(64-212) SKH(59-207) EE1(63-207) GFR(64-211) DGM(120-279) FES(75-223) AF1(58-207) MOS(80-227) SVK(53-200) 

APK    FLVKLEFSF-KDNSNLYMVMEY--------VPGGEMFSHLRR--IG--RFSEPHARFY--
D28    NIVRLYDIVHSDAHKLYLVFEF--------LD-LDLKRYMEGIPKDQ-PLGADIVKKF--
SKH    NIIQLVEVF-ETQERVYMVMEL--------ATGGELFDRIIA--KG--SFTERDATRV--
EE1    HIVELMDSW-EHGGFLYMQVEL--------CENGSLDRFLEE--QG--QLSRLDEFRVWK
GFR    HVCRLLGIC-LTS-TVQLITQL--------MPFGCLLDYVRE--HKD-NIGSQYLLNW--
DGM    DYVPMLDMK-GDIKYADIESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGF--
FES    NIVRLIGVC-TQKQPIYIVMEL--------VQGGDFLTFLRT--EGA-RLRMKTLLQM--
AF1    NILLFMGYM-TKD-NLAIVTQW--------CEGSSLYKHLHV--QET-KFQMFQLIDI--
MOS    IIMEFGGNV-TLHQVIYGAAGH--------PEGDAGEPHCRT--GG--QLSLGKCLKY--
SVK    AILPLLDLH-VVSGVTCLVLPK---------YQADLYTYLSR--RLN-PLGRPQIAAV--
           :                                            :          

APK    -AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG---YIQVTDFGFAK-RVKGR-----TW
D28    -MMQLCKGIAYCHSHRILHRDLKPQNLLINKDG---NLKLGDFGLARAFGVPLRAY---T
SKH    -LQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDC-L-MK
EE1    ILVEVALGLQFIHHKNYVHLDLKPANVMITFEG---TLKIGDFGMASVWPVPR-----GM
GFR    -CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ---HVKITDFGLAKLLGAEEKEYH-AE
DGM    -SYQVANGMDFLASKNCVHRDLAARNVLICEGK---LVKICDFGLARDIMRDSNY-I-SK
FES    -VGDAAAGMEYLESKCCIHRDLAARNCLVTEKN---VLKISDFGMSRE--AADGIYA-AS
AF1    -ARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL---TVKIGDFGLATVKSRWSGSQQ-VE
MOS    -SLDVVNGLLFLHSQSIVHLDLKPANILISEQD---VCKISDFGCSEKLEDLLCFQTPSY
SVK    -SRQLLSAVDYIHRQGIIHRDIKTENIFINTPE---DICLGDFGAACFVQGSRSSPF-PY
               . :       : *: . * :           : *** :              

APK    TL--CGTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEMAA-GYPPFFADQP
D28    HE--IVTLWYRAPEVLL--GGKQYSTGVDTWSIGCIFAEMCN-RKPIFSGDSE
SKH    TT--CGTPEYIAPEVLV---RKPYTNSVDMWALGVIAYILLS-GTMPFEDDNR
EE1    ER--EGDCEYIAPEVLA---NHLYDKPADIFSLGITVFEAAA-NIVL-PDNGQ
GFR    GG--KVPIKWMALESIL---HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPA
DGM    GS-TYLPLKWMAPESIF---NSLYTTLSDVWSFGILLWEIFTLGGTPYPELPM
FES    GGLRQVPVKWTAPEALN---YGRYSSESDVWSFGILLWETFSLGASPYPNLSN
AF1    QP--TGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSRDQI
MOS    PL--GGTYTHRAPELLK---GEGVTPKADIYSFAITLWQMTT-KQAPYSGERQ
SVK    GI--AGTIDTNAPEVLA---GDPYTTTVDIWSAGLVIFETAVHNASLFSAPRG
                  * * :            * :: .                   

AF1(3-54) APK(3-58) SKH(3-55) EE1(3-58) GFR(3-60) FES(18-71) MOS(3-56) DGM(3-62) 

AF1    VMLSTRIGSGSFGTVYKGKWHG-----DVAVKILKVVDPT---PEQ---FQAFRNEVAVL
APK    FERIKTLGTGSFGRVMLVKHME-----TGNHYAMKILDKQKVVKLK--QIEHTLNEKRIL
SKH    YDIKALIGRGSFSRVVRVEHRA-----TRQPYAIKMIETK--YREG---REVCESELRVL
EE1    FRNVTLLGSGEFSEVFQVEDPV-EK---TLKYAVKKLKVK-FSGPK--ERNRLLQEVSIQ
GFR    FKKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELREA--TSPK--ANKEILDEAYVM
FES    LVLGEQIGRGNFGEVFSGRLRA-DN----TLVAVKSCRET--LPPD--IKAKFLQEAKIL
MOS    VCLLQRLGAGGFGSVYKATYRG-------VPVAIKQVNKC--TKNRLASRRSFWAELNVA
DGM    LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKST--ARSS--EKQALMSELYGD
             :* * *. *                  :*                    *    

AF1    -RKT
APK    -QAV
SKH    -RRV
EE1    -RAL
GFR    -ASV
FES    -KQY
MOS    -RLR
DGM    LVDY
           

D28(3-63) EE1(3-61) GFR(3-63) FES(18-74) APK(3-61) 

D28    YKRLEKVGEGTYGVVYKALDLRPGQG-QRVVALKKIRL-ESEDEGVPSTAIREISLLKEL
EE1    FRNVTLLGSGEFSEVFQVEDPVEK---TLKYAVKKLKV-KFSGPKERNRLLQEVSIQRAL
GFR    FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE-A-TSPKANKEILDEAYVMASV
FES    LVLGEQIGRGNFGEVFSGRLRADN----TLVAVKSCRE-T-LPPDIKAKFLQEAKILKQY
APK    FERIKTLGTGSFGRVMLVKHMETGN----HYAMKILDKQKVVKLKQIEHTLNEKRILQAV
             :* * :. *                *:*                : *  :    

D28    KDD
EE1    KGH
GFR    DNP
FES    SHP
APK    NFP
       .  

DGM(281-328) GFR(212-259) FES(224-271) AF1(205-256) 

DGM    DQFYNAIKRGYRMAQP----AHASDEIYEIMQKCWEEKFETRPPFSQLVLLL
GFR    SEISSILEKGERLPQP----PICTIDVYMIMVKCWMIDADSRPKFRELIIEF
FES    QQTREFVEKGGRLPCP----ELCPDAVFRLMEQCWAYEPGQRPSFSAIYQEL
AF1    DQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
       .:    : :*   .        ..  :  :: .*       ** *  :   :

SKH(209-256) APK(205-248) D28(229-286) 

SKH    RLYRQI---LRGKYSYSG-------EPWPSVSNLAKDFIDRLLTVDPGARMTALQALR
APK    QIYEKI---VSGKVRFPS-----------HFSSDLKDLLRNLLQVDLTKRFGNLKDGV
D28    AIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAI
        :: .*      *  :.             ..    *:: .**  *   *:   :   

MOS(233-277) SVK(4-46) 

MOS    VVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLL
SVK    TIHGALTPGSEGCVFDSSHPDYPQRVIVKAGWYTSTSHE--ARLL
       .:   * *. ...**:.* *.     :::  * .*:::.  ****