PROBCONS version 1.09 multiple sequence alignment D28 ---------------ANYKRLEKVGEGTYGVVYKALDLR-P-GQGQRVVALKKIRLES-E SKH ---------------AKYDIKALIGRGSFSRVVRVEHRA-----TRQPYAIKMIETKY-- APK ---------------DQFERIKTLGTGSFGRVMLVKHME-----TGNHYAMKILDKQKVV EE1 ---------------TRFRNVTLLGSGEFSEVFQVEDPV----EKTLKYAVKKLKVKF-S GFR ---------------TEFKKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELREAT-- DGM ---------------DQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTA-- FES VLNRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETL-- AF1 ---------------SEVMLSTRIGSGSFGTVYKGKWHG--------DVAVKILKVVD-P MOS ---------------EQVCLLQRLGAGGFGSVYKATYRG-------VPVAIKQVNKCT-K SVK ---------------MGFTIHGALTPGSEGCVFDSSHPD-----YPQRVIVKAGW----- : * . * : :* D28 DE-GVPSTAIREIS-----LLKELK-DDNIVRLY-----------------DIVHS---- SKH -R-EGREVCESELR-----VLRRVR-HANIIQLV-----------------EVFE----- APK KL-KQIEHTLNEKR-----ILQAVN-FPFLVKLE-----------------FSFK----- EE1 GP-KERNRLLQEVS-----IQRALKGHDHIVELM-----------------DSWE----- GFR SP-KANKEILDEAY-----VMASVD-NPHVCRLL-----------------GICL----- DGM RS-SEKQALMSELYGDLVDYLHRNK-HTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLN FES PP-DIKAKFLQEAK-----ILKQYS-HPNIVRLI-----------------GVCT----- AF1 TP-EQFQAFRNEVA-----VLRKTR-HVNILLFM-----------------GYMT----- MOS NRLASRRSFWAELN-----V-ARLR-HDNIVRVV-----------------AAST----- SVK -----YTSTSHEAR-----LLRRLD-HPAILPLL-----------------DLHV----- * : . D28 ---DAH------KLYLVFEFLD-LDLKR----------------YMEGIPK--------- SKH ---TQE------RVYMVMELATGGELFD----------------RIIAK----------- APK ---DNS------NLYMVMEYVPGGEMFS----------------HLRRI----------- EE1 ---HGG------FLYMQVELCENGSLDR----------------FLEEQ----------- GFR ---T-S------TVQLITQLMPFGCLLD----------------YVREH----------- DGM LTGESD------GGYMDMSKDESIDYVP----------------MLDMKGDIKYADIESP FES ---QKQ------PIYIVMELVQGGDFLT----------------FLRTE----------- AF1 ---K-D------NLAIVTQWCEGSSLYK----------------HLHVQ----------- MOS ---R-TPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRT------------ SVK ---VSG------VTCLVLPKYQ-ADLYT----------------YLSRR----------- : . D28 -------------------------DQPL---GADIVKKFMMQLCKGIAYCHSHRILHRD SKH --------------------------GSF---TERDATRVLQMVLDGVRYLHALGITHRD APK --------------------------GRF---SEPHARFYAAQIVLTFEYLHSLDLIYRD EE1 --------------------------GQLSRLDEFRVWKILVEVALGLQFIHHKNYVHLD GFR -------------------------KDNI---GSQYLLNWCVQIAKGMNYLEDRRLVHRD DGM SYMAPYDNYVPSAPERTYRATLINDSPVL---SYTDLVGFSYQVANGMDFLASKNCVHRD FES -------------------------GARL---RMKTLLQMVGDAAAGMEYLESKCCIHRD AF1 -------------------------ETKF---QMFQLIDIARQTAQGMDYLHAKNIIHRD MOS -------------------------GGQL---SLGKCLKYSLDVVNGLLFLHSQSIVHLD SVK -------------------------LNPL---GRPQIAAVSRQLLSAVDYIHRQGIIHRD : . : : * D28 LKPQNLLINKD---GNLKLGDFGLARAFGVPLRAY--T--H-E-IVTLWYRAPEVLLG-- SKH LKPENLLYYHPGTDSKIIITDFGLASARKKGDDCL--M--KTT-CGTPEYIAPEVLV--- APK LKPENLLIDQQ---GYIQVTDFGFAKRVKGR------T--WTL-CGTPEYLAPEIIL--- EE1 LKPANVMITFE---GTLKIGDFGMASVWPVPR-----GMER---EGDCEYIAPEVLA--- GFR LAARNVLVKTP---QHVKITDFGLAKLLGAEEKEY--H-AEGG-KVPIKWMALESIL--- DGM LAARNVLICEG---KLVKICDFGLARDIMRDSNYI--S-KGST-YLPLKWMAPESIF--- FES LAARNCLVTEK---NVLKISDFGMSREAADG--IYAAS-GGLR-QVPVKWTAPEALN--- AF1 MKSNNIFLHEG---LTVKIGDFGLATVKSRWSGSQ--Q-VEQP-TGSVLWMAPEVIRMQD MOS LKPANILISEQ---DVCKISDFGCSEKLEDLLCFQ--T-PSYPLGGTYTHRAPELLK--- SVK IKTENIFINTP---EDICLGDFGAACFVQGSRSSP--F-PYGI-AGTIDTNAPEVLA--- : . * : : *** : * * : D28 GKQYSTGVDTWSIGCIFAEMCN-RK-P-IFSG---------D-SEIDQIFKIFRVLG--- SKH RKPYTNSVDMWALGVIAYILLS-GT-M-PFED---------D-NRTRLYRQILRGKY--- APK SKGYNKAVDWWALGVLIYEMAA-GY-P-PFFA---------D-QPIQIYEKIVSGKV--- EE1 NHLYDKPADIFSLGITVFEAAA-NIVL-PDNG--------------QSWQKLRSGDL--- GFR HRIYTHQSDVWSYGVTVWELMTFGS-K-PYDG---------I-PASEISSILEKGER--- DGM NSLYTTLSDVWSFGILLWEIFTLGG-T-PYPE---------LPMNDQFYNAIKRGYR--- FES YGRYSSESDVWSFGILLWETFSLGA-S-PYPN---------L-SNQQTREFVEKGGR--- AF1 NNPFSFQSDVYSYGIVLYELMT-GE-L-PYSR---------D-Q---IIFMVGRGYA--- MOS GEGVTPKADIYSFAITLWQMTT-KQ-A-PYSG---------E-RQH-ILYAVVAYDL--- SVK GDPYTTTVDIWSAGLVIFETAV-HN-ASLFSAPRGPKRGPCD-SQITRIIRQAQ--VHVD * :: . : D28 TPNEAIWPDIVYLPDFKPSFPQ-------W------------------RRKD----LSQV SKH SY------------------SG---E------------------PWPSVSNL----A--- APK RF------------------PS-------H------------------FSSD----L--- EE1 SD-----------------APR-------LSSTDNGSSLTSSSRETPANSIIGQGGL--- GFR LP-----------------QPP-------I------------------CTID----V--- DGM MA-----------------QPA-------H------------------ASDE----I--- FES LP-----------------CPE-------L------------------CPDA----V--- AF1 SP-----------------DLSKLYK---N------------------CPKA----M--- MOS RP-----------------SLSAAVFEDSL------------------PGQR----L--- SVK EF--------------SP-HPE-------S------------------------------ .* *: D28 VPSLDPRGIDLLDKLLA-YDPINRISARRAAIHP-------YF---QES SKH --------KDFIDRLLT-VDPGARMTALQALRHP-------WV---VSM APK --------KDLLRNLLQ-VDLTKRFGNLKDGVND-------IK---NHK EE1 --------DRVVEWMLS-PEPRNRPTIDQILATD-------EV---CWV GFR --------YMIMVKCWM-IDADSRPKFRELIIEF-------SK---MAR DGM --------YEIMQKCWE-EKFETRPPFSQLVLLLERLLGEGYK---KKY FES --------FRLMEQCWA-YEPGQRPSFSAIY---------------QEL AF1 --------KRLVADCVK-KVKEERPLFPQILSSI-------EL---LQH MOS --------GDVIQRCWR-PSAAQRPSARLLLVDL-------TS---LKA SVK ---------RLTSRYRSRAAGNNRPPYTRPAWTR-------YYKMDIDV . *