PROBCONS version 1.10 multiple sequence alignment D28 ---------------ANYKRLEKVGEGTYGVVYKALDLRPG--QGQRVVALKKIRLES-- SKH ---------------AKYDIKALIGRGSFSRVVRVEHRAT-----RQPYAIKMIETKY-- APK ---------------DQFERIKTLGTGSFGRVMLVKHMET-----GNHYAMKILDKQKVV EE1 ---------------TRFRNVTLLGSGEFSEVFQVEDPVE----KTLKYAVKKLKVKF-- GFR ---------------TEFKKIKVLGSGAFGTVYKGLWIPEG-EKVKIPVAIKELREAT-- DGM ---------------DQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTA-- FES VLNRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRAD-----NTLVAVKSCRETL-- AF1 ---------------SEVMLSTRIGSGSFGTVYKGKWHGD--------VAVKILKVVD-- MOS ---------------EQVCLLQRLGAGGFGSVYKATYRG-------VPVAIKQVNKCT-- SVK ---------------MGFTIHGALTPGSEGCVFDSSHPD---------YPQRVIVK---- : * . * . .: . : D28 EDE--GVPSTAIREIS-----LLKELK-DDNIVRL-----------------YDIVHSDA SKH R----EGREVCESELR-----VLRRVR-HANIIQL-----------------VEVFET-Q APK K-L--KQIEHTLNEKR-----ILQAVN-FPFLVKL-----------------EFSFKD-N EE1 SGP--KERNRLLQEVS-----IQRALKGHDHIVEL-----------------MDSWEH-G GFR S-P--KANKEILDEAY-----VMASVD-NPHVCRL-----------------LGICLT-- DGM R-S--SEKQALMSELYGDLVDYLHRNK-HTFLQRHSNKHCPPSAELYSNALPVGFSLP-- FES P-P--DIKAKFLQEAK-----ILKQYS-HPNIVRL-----------------IGVCTQ-K AF1 PTP--EQFQAFRNEVA-----VLRKTR-HVNILLF-----------------MGYMTK-- MOS K-NRLASRRSFWAELN------VARLR-HDNIVRV-----------------VAASTR-T SVK --A--GWYTSTSHEAR-----LLRRLD-HPAILPL-----------------LDLHVV-S * : D28 -----HKL---------YLV------FEFLD-----LDL--------------KRYMEG- SKH -----ERV---------YMV------MELAT----GGEL--------------FDRIIA- APK -----SNL---------YMV------MEYVP----GGEM--------------FSHLRR- EE1 -----GFL---------YMQ------VELCE----NGSL--------------DRFLEE- GFR -----STV---------QLI------TQLMP----FGCL--------------LDYVRE- DGM -----SHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVP-- FES -----QPI---------YIV------MELVQ----GGDF--------------LTFLRT- AF1 -----DNL---------AIV------TQWCE----GSSL--------------YKHLHV- MOS PAGSNSLG---------TII------MEFGG----NVTL--------------HQVIYGA SVK -----GVT---------CLV------LPKY-----QADL--------------YTYLSR- : : : D28 --IP----------KD--QPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKD SKH --------------KG---SFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHP APK --------------IG---RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ EE1 --------------QGQLSRLDEFRVWKILVEVALGLQFIHHKNYVHLDLKPANVMITFE GFR --------------HK--DNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP DGM -SAPERTYRATLINDS--PVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEG FES --------------EG--ARLRMKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEK AF1 --------------QE--TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEG MOS AGHPEGDAGEPHCRTG--GQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQ SVK --------------RL--NPLGRPQIAAVSRQLLSAVDYIHRQGIIHRDIKTENIFINTP . ** . . : . : : *: . * : D28 ---GNLKLGDFGLARAFGV----PL-R--AYTHE-------IVTLWYRAPEVLLG--GKQ SKH GTDSKIIITDFGLASARKK----GD-DCLMKTTC---G-----TPEYIAPEVLV---RKP APK ---GYIQVTDFGFAKRVK-----GR----TWTLC---G-----TPEYLAPEIIL---SKG EE1 ---GTLKIGDFGMASVWPV----PR-G---MERE---G-----DCEYIAPEVLA---NHL GFR ---QHVKITDFGLAKLLGA----EE-K--EYHAE---GG--KVPIKWMALESIL---HRI DGM ---KLVKICDFGLARDIMR----DS----NYISK---GS-TYLPLKWMAPESIF---NSL FES ---NVLKISDFGMSREAA------D-G--IYAAS---GGLRQVPVKWTAPEALN---YGR AF1 ---LTVKIGDFGLATVKSR----WS-G--SQQVEQPTG-----SVLWMAPEVIRMQDNNP MOS ---DVCKISDFGCSEKLEDLLCFQT-P--SYPLG---G-----TYTHRAPELLK---GEG SVK ---EDICLGDFGAACFVQG----SRSSPFPYGIA---G-----TIDTNAPEVLA---GDP : *** : : *. : * * : D28 YSTGVDTWSIGCIFAEMCN-RK-PIFSGDS--------EIDQIFKIF-RVLGT----PNE SKH YTNSVDMWALGVIAYILLS-GT-MPFEDDN--------RT-RLYRQILRGKYSYSGEPWP APK YNKAVDWWALGVLIYEMAA-GY-PPFFADQ--------PI-QIYEKIVSGK-V----RFP EE1 YDKPADIFSLGITVFEAAA-NIVLPDNGQ-------------SWQKLRSGDLS----DAP GFR YTHQSDVWSYGVTVWELMTFGS-KPYDGIP--------AS-EISSILEKGERL----PQP DGM YTTLSDVWSFGILLWEIFTLGG-TPYPELP-------MND-QFYNAIKRGYRM----AQP FES YSSESDVWSFGILLWETFSLGA-SPYPNLS--------NQ-QTREFVEKGGRL----PCP AF1 FSFQSDVYSYGIVLYELMT-GE-LPYSR-----------D-QIIFMVGRGY------ASP MOS VTPKADIYSFAITLWQMTT-KQ-APYSGER--------QH-ILYAVVAYDLRP----SLS SVK YTTTVDIWSAGLVIFETAV-HN-ASLFSAPRGPKRGPCDS-QITRIIRQAQ-V----HVD * :: . : . D28 AI----------------------WPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDL SKH SV----------------------S-NL-------------------------------- APK SH----------------------FSSD-------------------------------- EE1 RLSSTDNGSSLTSSSRETPANSIIGQGG-------------------------------- GFR PI----------------------CTID-------------------------------- DGM AH----------------------ASDE-------------------------------- FES EL----------------------CPDA-------------------------------- AF1 DLS---------KLYK----N---CPKA-------------------------------- MOS AA-----------VFE----DSL-PGQR-------------------------------- SVK EF----------------------SPHP-------------------------------- * . . :*: D28 LDKLLAYDPINRISAR----RAAI-H--PYF---QES-------------- SKH -----AKDFIDRLLTVD-PGARMT------------ALQ-ALRH-PWVVSM APK -----LKDLLRNLLQVD-LTKRF--G-----NLK-DG-VNDIKNHK----- EE1 -----LDRVVEWMLSPE-PRNRPTID-----QIL-ATDE-VC----WV--- GFR -----VYMIMVKCWMID-ADSRPKFR-----ELI-IEFS-KMAR------- DGM -----IYEIMQKCWEEK-FETRPPFS-----QLV-LLLE-RLLGEGYKKKY FES -----VFRLMEQCWAYE-PGQRPSFS-----AIY-QEL------------- AF1 -----MKRLVADCVKKV-KEERPLFP-----QIL-SSIE-LLQH------- MOS -----LGDVIQRCWRPS-AAQRPSAR-----LLL-VDLT-SLKA------- SVK -----ESRLTSRYRSRAAGNNRPPYTRPAWTRYYKMDID-V---------- .: : . : .