10 366 SKH AKYDIKALIG RGSFSRVVRV EHRAT--RQP YAIKMIETKY ----REGRE- APK DQFERIKTLG TGSFGRVMLV KHMET--GNH YAMKILDKQK ----VVKLK- SVK MGFTIHGALT PGSEGCVFDS S--HP--DYP QRVIV----- --------KA D28 ANYKRLEKVG EGTYGVVYKA LDLRP--GQG QRVVALKKIR ----LESEDE EE1 TRFRNVTLLG SGEFSEVFQV EDPVE--KTL KYAVKKLKVK ----FSGPKE GFR TEFKKIKVLG SGAFGTVYKG LWI-PEGEKV KIPVAIKELR EATSPKANKE DGM DQLVLGRTLG SGAFGQVVEA TAHGLSHSQA TMKVAVKMLK STARSSEKQA FES ---VLNRAVP KDKWVLNHED LVLGEQIGRG NFGEVF---- -SGRLRADNT AF1 SEVMLSTRIG SGSFGTVYKG KWHGD----- ---VAVKILK ---------- MOS EQVCLLQRLG AGGFGSVYKA TYRG------ -VPVAIKQVN -----KCTKN -VC------- -------ESE ---L---RVL RRVR-HANII QLVEVFE--- -QI------- -------EHT ---LNEKRIL QAVN-FPFLV KLEFSFK--- GWY------- -------TST ---SHEARLL RRLD-HPAIL PLLDL-H--- GVP------- -------STA ---IREISLL KELK-DDNIV RLYDIVH--- --R------- -------NRL ---LQEVSIQ RALKGHDHIV ELMDSWE--- ILDEAY---- -VMASVDNPH VCRLLGICLT STVQLITQLM PFGCLL---- LMSELYGDLV DYLHRNKHTF LQRHSNKHCP PSAELYSNAL PVGFSLPSHL LVA------- --VKSCRETL PPDIKAKFL- QEAKILKQ-- ---YSHPNIV ---------- -VVDPTPEQF QAFRNEVAVL RKTRHVNILL FMGYM----- RLA------- -----SRRSF WAELN-VARL RHDNIVRVVA ASTRTPAGSN ---------- ---TQE-RVY MVMELAT-GG ---------- ---------- ---------- ---DNS-NLY MVMEYVP-GG ---------- ---------- ---------- ---VVSGVTC LVLPKYQ-AD LY-------- ---------- ---------- ---SDAHKLY LVFEFLD-LD LK-------- ---------- ---------- ----HGGFLY MQVELCENGS LD-------- ---------- ---------- ---------D YVR--EHKDN I--------- ---------- NLTGESDGGY MDMSKDESID YVPMLDMKGD IKYADIESPS YMAPYDNYVP RLIGVC---- ---TQKQPIY IVMELVQGGD F--------- ---------- ---------- ----TKDNLA IVTQWCEGSS L--------- ---------- SLGTIIMEFG GNVTLHQVIY GAAGHPEGDA ---------- ---------- -----ELFDR IIAKGS-FTE RDATRVLQMV LDGVRYLHAL GITHRDLKPE -----EMFSH LRRIGR-FSE PHARFYAAQI VLTFEYLHSL DLIYRDLKPE -----TYLS- -RRLNP-LGR PQIAAVSRQL LSAVDYIHRQ GIIHRDIKTE -----RYMEG IPKDQP-LGA DIVKKFMMQL CKGIAYCHSH RILHRDLKPQ -----RFLEE QGQLSR-LDE FRVWKILVEV ALGLQFIHHK NYVHLDLKPA ---------- --------GS QYLLNWCVQI AKGMNYLEDR RLVHRDLAAR SAPERTYRAT LINDSPVLSY TDLVGFSYQV ANGMDFLASK NCVHRDLAAR -------LTF LRTEGARLRM KTLLQMVGDA AAGMEYLESK CCIHRDLAAR -------YKH LHVQETKFQM FQLIDIARQT AQGMDYLHAK NIIHRDMKSN -------GEP HCRTGGQLSL GKCLKYSLDV VNGLLFLHSQ SIVHLDLKPA NLLYYHPGTD SKIIITDFGL AS-ARKKGDD CLMKTTCGTP EYIAPEVLV- NLLIDQQGY- --IQVTDFGF AK--RVKGRT W---TLCGTP EYLAPEIIL- NIFINTPED- --ICLGDFGA ACFVQGSRSS PFPYGIAGTI DTNAPEVLA- NLLINKDGN- --LKLGDFGL AR-AFGVPLR AYTHEIVTLW YRAPEVLLG- NVMITFEGT- --LKIGDFGM AS----VWPV PRGMEREGDC EYIAPEVLA- NVLVK-TPQ- -HVKITDFGL AKLLGAEEKE YHAEGGKVPI KWMALESIL- NVLIC-EGK- -LVKICDFGL ARDIMRDSNY ISKGSTYLPL KWMAPESIF- NCLVT-EKN- -VLKISDFGM SREAADGIYA ASGGLRQVPV KWTAPEALN- NIFLH-EGL- -TVKIGDFGL ATVKSRWSGS QQVEQPTGSV LWMAPEVIRM NILIS-EQD- -VCKISDFGC SEKLEDLLCF QTPSYPLGGT -YTHRAPELL --RKPYTNSV DMWALGVIAY ILLSGTMPFE DDNRT-RLYR ---------Q --SKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPI-QIYE ---------K --GDPYTTTV DIWSAGLVIF ETAVHNASLF SAP---RGPK RGPCDSQITR --GKQYSTGV DTWSIGCIFA EMCNRKPIFS GDSEIDQIFK IFRVLGTPNE --NHLYDKPA DIFSLGITVF E-AAANIVLP DNGQSWQKLR ----SGDLSD --HRIYTHQS DVWSYGVTVW ELMTFGSKPY DGIPASE-IS -----SILEK --NSLYTTLS DVWSFGILLW EIFTLGGTPY PELPMNDQFY -----NAIKR --YGRYSSES DVWSFGILLW ETFSLGASPY PNL-SNQQTR -----EFVEK QDNNPFSFQS DVYSYGIVLY ELMT-GELPY SRDQIIFMVG -----RGYAS KGEGV-TPKA DIYSFAITLW QMTTKQA-PY SG-ERQHILY -----AVVAY ILRGKYSYSG EPWPS----- VSNLAK---- ------DFID RLLTVDPGAR IVSGKVRF-- -PSHF----- SSDL-K---- ------DLLR NLLQVDLTKR IIRQAQVHVD EFSP-HPESR LTSRYRSRAA GNNR------ -----PPYTR AIWPDIVYLP DFKPSFPQWR RKDLSQVVPS LDPRGIDLLD KLLAYDPINR APRLSSTDNG SSLTSSSRET PANSIIGQGG LD----RVVE WMLSPEPRNR GERLPQP-PI CTIDV----- YMIMVKC--- ------WMID ADSRPKFREL GYRMAQP-AH ASDEI----- YEIMQKC--- ------WEEK FETRPPFSQL GGRLPCP-EL CPDAV----- FRLMEQC--- ------WAYE PGQRPSFSAI PDLSKLY-KN CPKAM----- KRLVADC--- ------VKKV KEERPLFPQI DLRPSLS-AA VFEDS----- LPGQRLG--- ------DVIQ RCWRPSAAQR MTALQALRHP WVVSM- FGNLKDGVND IKNHK- PAWTR--YYK MDIDV- ISARRAAIHP YFQES- PTIDQILATD EVCWV- IIEFSKMAR- ------ VLLLERLLGE GYKKKY YQEL------ ------ LSSIELLQH- ------ PSARLLLVDL TSLKA-