CLUSTAL W (1.74) multiple sequence alignment D28 ANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTA SKH -------------------------------------------------- APK -------------------------------------------------- EE1 -------------------------------------------------- GFR -------------------------------------------------- DGM -------------------------------------------------- FES -------------------------------------------------- AF1 -------------------------------------------------- MOS -------------------------------------------------- SVK -------------------------------------------------- D28 IR------------------------------------------------ SKH --AKYD------IK-------AL-------------------------IG APK ------D-QFERIK-------TL--------------------------G EE1 -------TRFRNV--------TL-------------------------LG GFR -------TEFKKIK-------VL--------------------------G DGM -------------------------------------------------- FES -----------------------VLNRAVPKDKWVLNHE--DLVLGEQIG AF1 ---------------------------------------S-EVMLSTRIG MOS ----------------------------------------EQVCLLQRLG SVK --------------MGFTIHGAL--------------------------T D28 -------------------------------------------------- SKH RGSFSRVVR---V------------------------------------- APK TGSFGRVML---V------------------------------------- EE1 SGEFSEVFQ---V------------------------------------- GFR SGAFGTVYKGLWI------------------------------------- DGM -------------DQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVK FES RGNFGEVFS---G------------------------------------- AF1 SGSFGTVYKGKW-------------------------------------- MOS AGGFGSVYKATY-------------------------------------- SVK PGSEGCVFDSSH-------------------------------------- D28 -------------------------------------------------- SKH ---------------------------------------EH-RATRQPYA APK ---------------------------------------KH-METGNHYA EE1 ---------------------------------------EDPVEKTLKYA GFR ---------------------------------------PEGEKVKIPVA DGM MLKSTARSSEKQALMSELYGDLVDYLHRNKHTFLQRHSNKH-CPPSAELY FES ---------------------------------------RL-RADNTLVA AF1 ----------------------------------------HGD-----VA MOS ----------------------------------------RG----VPVA SVK ----------------------------------------PD----YPQR D28 ----------------------EISL-LK---ELK-D-DNIVRLYDIV-H SKH IKMIET-KYREGREVCES----ELRV-LR---RVR-H-ANIIQLVEVF-E APK MKILDKQKVVKLKQIEHT--LNEKRI-LQ---AVN-F-PFLVKLEFSF-K EE1 VKKLKV-KFSGPKERNRL--LQEVSI-QR---ALKGH-DHIVELMDSW-E GFR IKELRE-ATS-PKANKEI--LDEAYV-MA---SVD-N-PHVCRLLGIC-L DGM SNALPV-GFSLPSHLNLTGESDGGYMDMSKDESID-YVPMLDMKGDIK-Y FES VKSCRE-TLP-PDIKAKF--LQEAKI-LK---QYS-H-PNIVRLIGVC-T AF1 VKILKV-VDPTPEQFQAF--RNEVAV-LR---KTR-H-VNILLFMGY--M MOS IKQVNKCTKNRLASRRSF--WAELNV-AR----LR-H-DNIVRVVAASTR SVK V-IVKA-GWY-TS----T--SHEARL-LR---RLD-H-PAILPLLDLH-V D28 S---DAHK-LY--LV-FEF-L-DLDL-K-R--Y-MEG-IP--KDQP-LG- SKH T---Q-ER-VY--MV-ME--L-ATGG-E-L--F-DRI-IA--KGSF-TE- APK D---N-SN-LY--MV-ME--Y-VPGG-E-M--F-SHL-RR--IGRF-SE- EE1 H---G-GF-LY--MQ-VE--L-CENG-S-L----DRF-LEE-QGQL-SR- GFR T---S-T--VQ--LI-TQ--L-MPFG-C-L--L-DYV-RE-HKDN--IG- DGM A---DIESPSY--MAPYD-NY-VPSAPERT--Y-RAT-LI--NDSPVLSY FES Q---K-QP-IY--IV-ME--L-VQGG-D-F--L-TFL-RT-EGARL-RM- AF1 T---K-DN-LA--IV-TQ--W-CEGS-S-L--Y-KHL-HV-QETKF-QM- MOS TPAGS-NS-LGT-II-MEF-GGNVTL-H-QVIYGAAG-HP--EGDA-GE- SVK V---S-G--VT-CLV-LP--K-YQA--D-L--Y-TYLSRR--LNPL-GR- D28 ADI-V-------KKFM----MQLCKGIAYCHSHRILHRDLKPQNLLI--- SKH RDA-T-------RVLQ----MVL-DGVRYLHALGITHRDLKPENLLYYHP APK PHA---------RFYA----AQIVLTFEYLHSLDLIYRDLKPENLLI--- EE1 LDE-F-------RVWKIL--VEVALGLQFIHHKNYVHLDLKPANVMI--- GFR SQY-L-------LNWC----VQIAKGMNYLEDRRLVHRDLAARNVLV--- DGM TDL-V-------G-FS----YQVANGMDFLASKNCVHRDLAARNVLI--- FES KTL-L-------Q-MV----GDAAAGMEYLESKCCIHRDLAARNCLV--- AF1 FQL-I-------D-IA----RQTAQGMDYLHAKNIIHRDMKSNNIFL--- MOS PHCRTGGQLSLGKCLK--YSLDVVNGLLFLHSQSIVHLDLKPANILI--- SVK PQI-A-------A-VS----RQLLSAVDYIHRQGIIHRDIKTENIFI--- D28 NKDGNL-KLGDFGLA---RA-F--GV--PLRAYTHEI-----V-TL-WYR SKH GTDSKI-IITDFGLASA-RK-K--GD--DCLMKT-TC-----G-TP-EYI APK DQQGYI-QVTDFGFA---KRVK--G-----RTWT-LC-----G-TP-EYL EE1 TFEGTL-KIGDFGMA---SV-W--PV--P-RGME-RE-----G-DC-EYI GFR KTPQHV-KITDFGLA---KL-L--GA--EEKEYHAEGG----K-VPIKWM DGM C-EGKLVKICDFGLA---RD-I---M--RDSNYISKGS----TYLPLKWM FES T-EKNVLKISDFGMS---RE-A---A---DGIYAASGGLR--Q-VPVKWT AF1 H-EGLTVKIGDFGLATV-KS-RWSGS--QQVEQP-T------G-S-VLWM MOS S-EQDVCKISDFGCSEKLED-L---LCFQTPSYP-LG-----G-TY-THR SVK NTPEDIC-LGDFGAA---CFVQ--GS--RSSPFP-YG---IAG-TI-DTN D28 APEVL-L--GGKQYSTGVDTWSIGCI-FA-EMCN-RKPIFS---G---DS SKH APEVL-V--R-KPYTNSVDMWALGVIAYI-LLSG-TMP-FE---D---DN APK APEII-L--S-KGYNKAVDWWALGVLIYE-MAAG-YPP-FF---A---DQ EE1 APEVL-A--N-HLYDKPADIFSLGITVFE-AAANIVLP-DN---G---QS GFR ALESI-L--H-RIYTHQSDVWSYGVTVWELMTFG-SKP-YD---GIP-AS DGM APESI-F--N-SLYTTLSDVWSFGILLWEIFTLG-GTP-YP---ELP-MN FES APEAL-N--Y-GRYSSESDVWSFGILLWETFSLG-ASP-YP---NLS-NQ AF1 APEVIRMQDN-NPFSFQSDVYSYGIVLYELMT-G-ELP-YS---R---D- MOS APE-L-L--KGEGVTPKADIYSFAITLWQ-MTTK-QAP-YS---G---ER SVK APE-V-L--AGDPYTTTVDIWSAGLVIFETAVHN-ASL-FSAPRG--PKR D28 E-ID-QIFK-IFR-VLGTPNEAIW-PD-I-VYLP-DFK--PSFPQWRRKD SKH R-TR-LYRQ-ILRGKYSYSGEP-W-PS-V-SNLAKDF------------- APK P-IQ-IYEK-IVSGKVRF---P-S-HF-S-SDLK-DL------------- EE1 W-QK-LRSG-DLSDAPRL---S-S-TD-NGSSLTSSSRETPANSIIGQGG GFR E-IS-SILE---KGE-RL---P-Q-PP-I--------------------- DGM ---D-QFYNAIKRGY-RM---A-Q-PA-H--------------------- FES Q-TR-EFVE---KGG-RL---P-C-PE-L--------------------- AF1 Q-I---IFM-VGRGY-AS---P-DLSK-L--------------------- MOS QHI---LYA-VVAYDLR----P-SLSAAV--------------------- SVK GPCDSQITR-IIRQA-QV---H-V-DE-F--------------------- D28 LSQVVP---SLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES----- SKH ---------------------------------------------IDRLL APK ---------------------------------------------LRNLL EE1 LDRVVEWMLSPEPRNRPTIDQILATDEV---------------------- GFR -------------------------------------------------- DGM -------------------------------------------------- FES -------------------------------------------------- AF1 -------------------------------------------------- MOS -------------------------------------------------- SVK -------------------------------------------------- D28 -------------------------------------------------- SKH TVDPGARMTALQALRHPWVVSM---------------------------- APK QVDLTKRFGNLK----------DGVNDIKNHK------------------ EE1 --------------------------------CWV--------------- GFR --------------------------------------C-T-IDVYMIMV DGM --------------------------------------A-S-DEIYEIMQ FES --------------------------------------C-P-DAVFRLME AF1 -----------------------------------YKNC-P-KAMKRLVA MOS -----------------------------------FEDSLPGQRLGDVIQ SVK --------------------------------------S-P-HPESRLTS D28 -------------------------------------------------- SKH -------------------------------------------------- APK -------------------------------------------------- EE1 -------------------------------------------------- GFR KCWMIDAD--SRPKFRELIIEFSKMAR----------------------- DGM KCWEEKFE--TRPPFSQLVL-------LLERLLGEGYKKKY--------- FES QCWAYEPG--QRPSFS-------------------------AIYQEL--- AF1 DCVKKVKE--ERPLFPQILS-------SIELL---------------QH- MOS RCWRPSAA--QRPSARLLLVDLTSL------------------------K SVK R-YRSRAAGNNRPPYTR--------------------------------- D28 -------------- SKH -------------- APK -------------- EE1 -------------- GFR -------------- DGM -------------- FES -------------- AF1 -------------- MOS A------------- SVK -PAWTRYYKMDIDV