PCMA multiple sequence alignment (CLUSTAL format) GFR T---------------EFKKIKVLGSGAFGTVYKGLW-IPEGEKVKIPVAIKELREATS- DGM D---------------QLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTAR- FES VLNRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRL----RADNT-LVAVKSCRETLP- AF1 S---------------EVMLSTRIGSGSFGTVYKGKW----HGD----VAVKILKVVDP- MOS E---------------QVCLLQRLGAGGFGSVYKATY----RGV---PVAIKQVNKCTK- EE1 T---------------RFRNVTLLGSGEFSEVFQVED----PVEKTLKYAVKKLKVKFS- SKH A---------------KYDIKALIGRGSFSRVVRVEH----RAT-RQPYAIKMIETKY-- APK D---------------QFERIKTLGTGSFGRVMLVKH----MET-GNHYAMKILDKQKVV D28 A---------------NYKRLEKVGEGTYGVVYKALD-LR-PGQGQRVVALKKIRLESE- SVK M---------------GFTIHGALTPGSEGCVFDSSH----PDYPQ-RVIVKAG------ : * . * :* GFR -P--KANKEILDEA-----YVMASVD-NPHVCRLLGICLTS-T-V------QLITQLMPF DGM -S--SEKQALMSELYGDLVDYLHRNK-HTFLQRHSNKHCPP-S-A------ELYSNALPV FES -P--DIKAKFLQEA-----KILKQYS-HPNIVRLIGVCTQK-QPI------YIVMELVQG AF1 TP--EQFQAFRNEV-----AVLRKTR-HVNILLFMGYMTKD-N-L------AIVTQWCEG MOS -NRLASRRSFWAEL-----NVAR-LR-HDNIVRVVAASTRT-P-AGSNSLGTIIMEFGGN EE1 GP--KERNRLLQEV-----SIQRALKGHDHIVELMDSWEHG-GFL------YMQVELCEN SKH -R--EGREVCESEL-----RVLRRVR-HANIIQLVEVFETQ-ERV------YMVMELATG APK KL--KQIEHTLNEK-----RILQAVN-FPFLVKLEFSFKDN-SNL------YMVMEYVPG D28 DE--GVPSTAIREI-----SLLKELK-DDNIVRLYDIVHSDAHKL------YLVFEFLDL SVK -----WYTSTSHEA-----RLLRRLD-HPAILPLLDLHVVS-GVT------CLVLPKYQA * : : GFR G--CLLDYV--------------------------------------------------- DGM GFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSA FES G--DFLTFL--------------------------------------------------- AF1 S--SLYKHL--------------------------------------------------- MOS V--TLHQVI-YGAAGH---------PEG-------------------------DAG---- EE1 G--SLDRFL--------------------------------------------------- SKH G--ELFDRI--------------------------------------------------- APK G--EMFSHL--------------------------------------------------- D28 ---DLKRYM--------------------------------------------------- SVK ---DLYTYL--------------------------------------------------- GFR -----R--EHK--DN----IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ DGM PERTYR--ATL--INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGK FES -----R--TEG--AR----LRMKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKN AF1 -----H--VQE--TK----FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL MOS -EPHCR--T-G--GQ----LSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQD EE1 -----E--EQGQLSR----LDEFRVWKILVEVALGLQFIHHKNYVHLDLKPANVMITFEG SKH -----I--AKG---S----FTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPG APK -----R--RIG---R----FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG D28 -----EGIPKD--QP----LGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDG SVK -----S--RRL--NP----LGRPQIAAVSRQLLSAVDYIHRQGIIHRDIKTENIFINTPE : . : : *: . * : GFR ---HVKITDFGLAKLLGAEEKEYHAEGGKV-PIKWMALESILH---RIYTHQSDVWSYGV DGM ---LVKICDFGLARDIMRDSNYISKGSTYL-PLKWMAPESIFN---SLYTTLSDVWSFGI FES ---VLKISDFGMSREAADGIYAASGGLRQV-PVKWTAPEALNY---GRYSSESDVWSFGI AF1 ---TVKIGDFGLATVKSRWSGSQQVEQPTG-SVLWMAPEVIRMQDNNPFSFQSDVYSYGI MOS ---VCKISDFGCSEKLEDLLCFQTPSYPLGGTYTHRAPELLKG---EGVTPKADIYSFAI EE1 ---TLKIGDFGMASVWPVPR---GME-REG-DCEYIAPEVLAN---HLYDKPADIFSLGI SKH TDSKIIITDFGLASARKKGDDCL-MKTTCG-TPEYIAPEVLVR---KPYTNSVDMWALGV APK ---YIQVTDFGFAKRVKGRT----WTL-CG-TPEYLAPEIILS---KGYNKAVDWWALGV D28 ---NLKLGDFGLARAFGVP--LRAYTHEIV-TLWYRAPEVLLGG--KQYSTGVDTWSIGC SVK ---DICLGDFGAACFVQGSRSSPFPYGIAG-TIDTNAPEVLAG---DPYTTTVDIWSAGL : *** : * * : * :: . GFR TVWELMTFGSKPYDGI----------PAS-EISS---ILEKGE------------RLP-Q DGM LLWEIFTLGGTPYPEL----------PMNDQFYN---AIKRGY------------RMA-Q FES LLWETFSLGASPYPNL----------SNQ-QTRE---FVEKGG------------RLP-C AF1 VLYELMT-GELPYSR-------------D-QIIF---MVGRGY------ASPD--LSK-L MOS TLWQMTT-KQAPYSGE----------RQH-ILYA---VVAYDL------------RPS-L EE1 TVFEAAA-NIVLPD-------------NG-QSWQ---KLRSGDLSDAPRLSSTDNGSS-L SKH IAYILLS-GTMPFEDD----------NRT-RLYR---QILRGKYS---------YSGEPW APK LIYEMAA-GYPPFFAD----------QPI-QIYE---KI----VS---------GKVR-F D28 IFAEMCN-RKPIFSGD----------SEIDQIFKIFRVLGTPN------------EAI-W SVK VIFETAV-HNASLFSAPRGPKRGPCDSQITRIIRQAQV---HV------------DEF-S GFR PPI----------CTID----------VYM--------------IMVKCWMIDADSRPKF DGM PAH----------ASDE----------IYE--------------IMQKCWEEKFETRPPF FES PEL----------CPDA----------VFR--------------LMEQCWAYEPGQRPSF AF1 YKN----------CPKA----------MKR--------------LVADCVKKVKEERPLF MOS SAA----------VFED----SLPGQRLGD--------------VIQRCWRPSAAQRPSA EE1 TSSSRETPANSIIGQGG----------LDR--------------VVEWMLSPEPRNRPTI SKH PSV----------S-NL----------AKD--------------FIDRLLTVDPGARMTA APK PSH----------FSSD----------LKD--------------LLRNLLQVDLTKRFGN D28 PDI----------VYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISA SVK PHP-------E--SRLTS-----------------------R--YRSRAAGNNRPPYTRP GFR RELIIEFSKMAR------- DGM SQLVLLLERLLGEGYKKKY FES SAIYQEL------------ AF1 PQILSSIELLQH------- MOS RLLLVDLTSLKA------- EE1 DQILATDEVCWV------- SKH LQALRHPWVVSM------- APK LKDGVNDIKNHK------- D28 RRAAIHPYFQES------- SVK AWTRYYKMDIDV-------