CLUSTAL (-like) formatted alignment by MAFFT L-INS-i (v6.232b) D28 ---------------ANYKRLEKVGEGTYGVVYKALDL--RPGQGQRVVALKKIRLES-E SKH ---------------AKYDIKALIGRGSFSRVVRVEHRA-----TRQPYAIKMIETKY-- APK ---------------DQFERIKTLGTGSFGRVMLVKHME-----TGNHYAMKILDKQKVV EE1 ---------------TRFRNVTLLGSGEFSEVFQVEDPV----EKTLKYAVKKLKVKF-S GFR ---------------TEFKKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELREA--T DGM ---------------DQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKST--A FES VLNRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRET--L AF1 ---------------SEVMLSTRIGSGSFGTVYKGKWHG--------DVAVKILKVVD-P MOS ---------------EQVCLLQRLGAGGFGSVYKATYR-------GVPVAIKQVNKCTKN SVK ---------------MGFTIHGALTPGSEGCVFDSSHP---------DYPQRVI-----V : * . * . : D28 DEGVPSTAIREIS-----LLKELK-DDNIVRL-----------------YDIVHSDAHKL SKH -REGREVCESELR-----VLRRVR-HANIIQL-----------------VEVFETQE-RV APK KLKQIEHTLNEKR-----ILQAVN-FPFLVKL------------------EFSFKDNSNL EE1 GPKERNRLLQEVS-----IQRALKGHDHIVEL-----------------MDSWEHGG-FL GFR SPKANKEILDEAY-----VMASVD-NPHVCRL-----------------LGICLTST--V DGM RSSEKQALMSELYGDLVDYLHRNK-HTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLNL FES PPDIKAKFLQEAK-----ILKQYS-HPNIVRL-----------------IGVCTQKQ-PI AF1 TPEQFQAFRNEVA-----VLRKTR-HVNILLF-----------------MGYMTKDN--L MOS RLASRRSFWAELN------VARLR-HDNIVRV-----------------VAASTRTP--- SVK KAGWYTSTSHEAR-----LLRRLD-HPAILPL-----------------LDLHVVSG--V * : D28 -------YLVFEFL-DLDLKRYMEGIPKD------------------------------- SKH -------YMVMELATGGELFDRIIAK---------------------------------- APK -------YMVMEYVPGGEMFSHLRRI---------------------------------- EE1 -------YMQVELCENGSLDRFLEEQGQL------------------------------- GFR -------QLITQLMPFGCLLDYVREHK--------------------------------- DGM TGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLI FES -------YIVMELVQGGDFLTFLRTEG--------------------------------- AF1 -------AIVTQWCEGSSLYKHLHVQE--------------------------------- MOS AGSNSLGTIIMEFGGNVTLHQVIYGAA---------------------GHPEGDAGEPHC SVK -------TCLVLPKYQADLYTYLSRRL--------------------------------- : D28 ---QPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGN---LKLGDFGLAR SKH ---GSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLAS APK ---GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY---IQVTDFGFAK EE1 ---SRLDEFRVWKILVEVALGLQFIHHKNYVHLDLKPANVMITFEGT---LKIGDFGMAS GFR ---DNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH---VKITDFGLAK DGM NDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKL---VKICDFGLAR FES ---ARLRMKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNV---LKISDFGMSR AF1 ---TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLT---VKIGDFGLAT MOS RTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDV---CKISDFGCSE SVK ---NPLGRPQIAAVSRQLLSAVDYIHRQGIIHRDIKTENIFINTPED---ICLGDFGAAC : . : : *: . * : : *** : D28 AFG-V---PLRAYTHE--IVTLWYRAPEVLL--GGKQYSTGVDTWSIGCIFAEMCN-RKP SKH ARK-K---GDDCLMKTT-CGTPEYIAPEVLV---RKPYTNSVDMWALGVIAYILLS-GTM APK RVK------GRTWTL---CGTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEMAA-GYP EE1 VWP-----VPRGMER---EGDCEYIAPEVLA---NHLYDKPADIFSLGITVFEAAANIVL GFR LLG-A---EEKEYHAEGGKVPIKWMALESIL---HRIYTHQSDVWSYGVTVWELMTFGSK DGM DIM-R---DSNYISKGSTYLPLKWMAPESIF---NSLYTTLSDVWSFGILLWEIFTLGGT FES EAA-D---GIYAASGGLRQVPVKWTAPEALN---YGRYSSESDVWSFGILLWETFSLGAS AF1 VKS-R---WSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GEL MOS KLEDLLCFQTPSYPL---GGTYTHRAPELLK---GEGVTPKADIYSFAITLWQMTT-KQA SVK FVQGS---RSSPFPYGI-AGTIDTNAPEVLA---GDPYTTTVDIWSAGLVIFETAVHNAS * * : * :: . D28 IFSGD---------SEIDQIFKIFRVLGTPNEAIWPDIVY---------LPDFKPSFPQW SKH PFEDD-------NRTRLYRQILRGKYS--YSGEPWPSVSN---------LAK-------- APK PFFAD-------QPIQIYEKIVSGKVR-------FPSHFS-------------------- EE1 P-----------DNGQSWQKLRSGDLS------DAPRLSSTDNGSSLTSSSRETPANSII GFR PYDGI-------PASEISSILEKGERL------PQPPICT-------------------- DGM PYPEL------PMNDQFYNAIKRGYRM------AQPAHAS-------------------- FES PYPNL-------SNQQTREFVEKGGRL------PCPELCP-------------------- AF1 PYS----------RDQIIFMVGRGYAS--------PDLSK---------LYKNCP----- MOS PYSGE--------RQHILYAVVAYDLR--------PSLSA---------AVFEDSLPG-- SVK LFSAPRGPKRGPCDSQITRIIRQAQVH-VDEFSPHPE----------------------- . . * D28 RRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQ-------ES SKH -----------------DFIDRLLTVDPGARMTALQALRHPWVV-------SM APK --SDLK-----------DLLRNLLQVDLTKRFGNLKDGVNDIKN-------HK EE1 GQGGLD-----------RVVEWMLSPEPRNRPTIDQILATDEVC-------WV GFR --IDVY-----------MIMVKCWMIDADSRPKFRELIIEFSKM-------AR DGM --DEIY-----------EIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKY FES --DAVF-----------RLMEQCWAYEPGQRPSFSAIYQ------------EL AF1 --KAMK-----------RLVADCVKKVKEERPLFPQILSSIELL-------QH MOS --QRLG-----------DVIQRCWRPSAAQRPSARLLLVDLTSL-------KA SVK --SRLT-----------SRYRS--RAAGNNRPPYTRPAWTRYYKMDI----DV *