PIMA Multiple Sequence Alignment Results
Maximal Linkage Clustering
pat-ML ((((FES 471.68 GFR) 404.39 DGM) 296.78 (AF1 337.74 MOS)) 221.76 (((APK 486.02 SKH) 324.42 (D28 340.04 EE1)) 265.46 SVK))
Page 1.1
1 15 16 30 31 45 46 60 61 75 76 90
1 pat-ML --------------- --------------- --------------- --------------- --------------- -----------jrgg 4
2 FES --------------- --------------- --------------- ---VLNRAVPKDKWV LNHEDLVLGEQIGRG NFGEVFSGRLRAD-N 41
3 GFR --------------- --------------- --------------- --------------- ---TEFKKIKVLGSG AFGTVYKGLWIPEGE 27
4 DGM DQLVLGRTLGSGAFG QVVEATAHGLSHSQA TMKVAVKMLKSTARS SEKQALMSELYGDLV DYLHRNKHTFLQRHS NKHCPPSAELYSNA- 89
5 AF1 --------------- --------------- --------------- --------------- -------SEVMLSTR IGSGSFGTVYKGK-- 21
6 MOS --------------- --------------- --------------- --------------- -------EQVCLLQR LGAGGFGSVYKAT-- 21
7 APK --------------- --------------- --------------- --------------- --------------D QFERIKTL-GTGS-- 13
8 SKH --------------- --------------- --------------- --------------- --------------- AKYDIKALIGRGS-- 13
9 D28 --------------- --------------- --------------- --------------- --------------A NYKRLEKV-GEGT-- 13
10 EE1 --------------- --------------- --------------- --------------- --------------T RFRNVTLL-GSGE-- 13
11 SVK --------------- --------------- --------------- --------------- --------------- MGFTIHGALTPGS-- 13
Page 2.1
91 105 106 120 121 135 136 150 151 165 166 180
1 pat-ML gXgggVXXggggggg gggXXXjXXXXgggX XXXXXXXgrgggrXr XXrXcXggggggggg gggXXrgggggggfX ggXXrfXgggXXXXX 94
2 FES TL---VAVKSC---- -RETLPPDIKAK--F LQEAKILKQ-YSHPN IVRLIGVCT------ ---QKQ----P--IY I-VMELVQ--GGDFL 102
3 GFR KVKIPVAIKEL---- -REATSPKANKE--I LDEAYVMAS-VDNPH VCRLLGIC------- ---LTS----T--VQ L-ITQLMP--FGCLL 90
4 DGM -LP--VGF------- ---SLPSHLNLT--G ESDGGYM-D-MSKDE SIDYVPMLDMKGDIK YADIES----PSYMA P-YDNYVP--SAPER 155
5 AF1 -WHGDVAVKIL---- -KVVDPTPEQFQ--A FRNEVAVLR---KTR HVNILLFM------- -GYMTK-----DNLA -IVTQWCE--GSSLY 84
6 MOS -YRG-VPVAIK---- -QVNKCTKNRLA--S RRSFWAELN-VARLR HDNIVRVV------- -AASTRTPAGSNSLG TIIMEFGG--NVTLH 91
7 APK -FG-RVMLVKH---M ETGNHYAMKILDKQK VVKLKQIEHTLNEKR ILQAVNF--PFLVKL EFSFKD---NSN-LY M-VMEYVP--GGEMF 89
8 SKH -FS-RVVRVEH---R ATRQPYAIKMIE-TK YREGREVCES--ELR VLRRVRH--ANIIQL VEVFET---QER-VY M-VMELAT--GGELF 86
9 D28 -YG-VVYKALDLRPG QGQRVVALKKIRL-E SEDEGVPSTAIREIS LLKELK-D-DNIVRL YDIVHS---DAHKLY L-VFEFL---DLDLK 91
10 EE1 -FS-EVFQVED--PV EKTLKYAVKKLKV-K FSGPKERNRLLQEVS IQRALKGH-DHIVEL MDSWEH---GGF-LY M-QVELCE--NGSLD 90
11 SVK -EG-CVFDSSH---- ---PDYPQRVI--VK AGWYTSTSH---EAR LLRRLDHP-AILPLL DLHVVS---GVT-CL V-LPKYQADLYTYLS 83
Page 3.1
181 195 196 210 211 225 226 240 241 255 256 270
1 pat-ML rXgggcggggggggg ggggggXrXgXXXXX gggXXfXgggggjfX dfXXXXfXeXDcXjX NfffgggXXXXXfXc XDFGXjgggggggXX 184
2 FES TF---L--------- ------RTEGARLRM KTLLQMVGDAAAGME YLESKCCIHRDLAAR NCLV---TEKNVLKI SDFGMSR-----EAA 166
3 GFR DY---V--------- ------REHKDNIGS QYLLNWCVQIAKGMN YLEDRRLVHRDLAAR NVLV---KTPQHVKI TDFGLAKL---LGAE 156
4 DGM TYRATL--------- ------INDSPVLSY TDLVGFSYQVANGMD FLASKNCVHRDLAAR NVLI---CEGKLVKI CDFGLAR----DIMR 223
5 AF1 KH---L--------- -----HVQE-TKFQM FQLIDIARQTAQGMD YLHAKNIIHRDMKSN NIFL---HEGLTVKI GDFGLATVKSRWSGS 153
6 MOS QV---IYGAAGHPEG DAGEPHCRTGGQLSL GKCLKYSLDVVNGLL FLHSQSIVHLDLKPA NILI---SEQDVCKI SDFGCSEKLEDLLCF 175
7 APK SH---LR-------- ----RIGRFSEPHAR FYAAQIVL----TFE YLHSLDLIYRDLKPE NLLI---DQQGYIQV TDFGFAK------RV 151
8 SKH DR---II-------- ----AKGSFTERDAT RV-LQMVLD---GVR YLHALGITHRDLKPE NLLYYHPGTDSKIII TDFGLAS-----ARK 152
9 D28 RY---ME-------- ----GIPKDQPLGAD IV-KKFMMQLCKGIA YCHSHRILHRDLKPQ NLLI---NKDGNLKL GDFGLAR------AF 156
10 EE1 RF---LE-------- ----EQGQLSRLDEF RV-WKILVEVALGLQ FIHHKNYVHLDLKPA NVMI---TFEGTLKI GDFGMAS------VW 155
11 SVK RR---LN-------- ----PLGRPQIAAVS ---RQLL----SAVD YIHRQGIIHRDIKTE NIFI---NTPEDICL GDFGAA-------CF 141
Page 4.1
271 285 286 300 301 315 316 330 331 345 346 360
1 pat-ML ggggXjgXgggggXg ggggXXXXAXEXgcX XXgggXfrXXXDXdj XhfgggggggggXcX XXXgggggXgXXXXd gggggXXXXgXXXXg 274
2 FES DGIYAASG-----GL RQVPVKWTAPEA-LN YG---RYSSESDVWS FGI---------LLW ETF-----SLGASPY -----PNLS-NQQTR 227
3 GFR EKEYHAEG-----G- -KVPIKWMALES-IL HR---IYTHQSDVWS YGV---------TVW ELM-----TFGSKPY -----DGIP-ASEIS 215
4 DGM DSNYISKG-----ST Y-LPLKWMAPES-IF NS---LYTTLSDVWS FGI---------LLW EIF-----TLGGTPY -----PELPMNDQFY 284
5 AF1 QQVEQP-T-----G- ---SVLWMAPEV-IR MQDNNPFSFQSDVYS YGI---------VLY ELM-----T-GELPY S--RDQIIFMVGRGY 215
6 MOS QTPSYPLG-----G- ---TYTHRAPEL-LK GE---GVTPKADIYS FAI---------TLW QMT-----T-KQAPY SGERQHILYAVVAYD 237
7 APK ----KGRTW---TLC GT--PEYLAPEI-IL SK---GYNKAVDWWA LGV------LIYEMA AGYPPFFADQPIQIY ---EKIVSGKVRFPS 219
8 SKH ----KGDDCLMKTTC GT--PEYIAPEV-LV RK---PYTNSVDMWA LGV------IAYILL SGTMPFEDDNRTRLY ---RQILRGKYSYSG 223
9 D28 GVPLRAYT----HEI VT--LWYRAPEVLLG GK---QYSTGVDTWS IGCIFAEMCNRKPIF SGDSEI--DQIFKIF ---RVLGTPNEAIWP 232
10 EE1 PVP-RGME----RE- GD--CEYIAPEV-LA NH---LYDKPADIFS LGI---------TVF EAAANIVLPDNGQSW ---QKLRSGDLSDAP 221
11 SVK VQGSRSSPFPYG-IA GT--IDTNAPEV-LA GD---PYTTTVDIWS AGL---------VIF ETA-----VHNASLF ---SAPRGPKRGPC- 206
Page 5.1
361 375 376 390 391 405 406 420 421 435 436 450
1 pat-ML ggggXjgggXXfggg gXggggggggggggg gggXgggggXfXXrX ggggggXR------- --------------- -- 327
2 FES EFVEKG---GRL--- -PC-----------P ELCPDAVF-RLMEQC WAYEPGQRPSFSAIY QEL------------ -- 271
3 GFR SILEKG---ERL--- -PQ-----------P PICTIDVY-MIMVKC WMIDADSRPKFRELI IEFSKMAR------- -- 264
4 DGM NAIKRG---YRM--- -AQ-----------P AHASDEIY-EIMQKC WEEKFETRPPFSQLV LLLERLLGEGYKKKY -- 340
5 AF1 ASPDLS---KLY--- -KN-----------C PKAMKRLVADCVKKV K----EERPLFPQIL SSIELLQH------- -- 261
6 MOS LRPSLS---AAV--- -FE-----------D SLPGQRL-GDVIQRC ------WRPSAAQRP SARLLLVDLTSLKA- -- 286
7 APK H---FS---SDL--- -K------------- ---DL-LRNLLQVDL -----TKRFGNLKDG VNDIKNHK------- -- 255
8 SKH E--PWPS-VSNLA-- -K------------- ---DF-IDRLLTVDP -----GARMTALQAL RHPWVVSM------- -- 263
9 D28 DIVYLPDFKPSFPQW RRKDLSQVVPSLDPR -GID-LLDKLLAYDP -----INRISARRAA IHPYFQES------- -- 293
10 EE1 R-LSSTDNGSSLTSS SRETPAN---SIIGQ GGLDRVVEWMLSPEP -----RNRPTIDQIL ATDEVCWV------- -- 280
11 SVK ----DSQ-ITRI--- IR-----QAQVHVDE FSPHP--ESRLTSRY -----RSRAAGNNRP PYTRPAWTRYYKMDI DV 263
Sequential Branching Clustering
pat-SB (((((((((APK 486.02 SKH) 371.02 EE1) 334.41 D28) 323.71 GFR) 312.70 FES) 312.70 AF1) 291.40 SVK) 288.77 MOS) 273.21 DGM)
Page 1.1
1 15 16 30 31 45 46 60 61 75 76 90
1 pat-SB --------------- --------------- --------------- --------------- --------------- ----jXXjXcfXXXX 11
2 APK --------------- --------------- --------------- --------------- -------DQFERIKT L-GTGSFGRVMLVKH 22
3 SKH --------------- --------------- --------------- --------------- --------AKYDIKA LIGRGSFSRVVRVEH 22
4 EE1 --------------- --------------- --------------- --------------- -------TRFRNVTL L-GSGEFSEVFQVED 22
5 D28 --------------- --------------- --------------- --------------- -------ANYKRLEK V-GEGTYGVVYKALD 22
6 GFR --------------- --------------- --------------- --------------- -------TEFKKIKV L-GSGAFGTVYKGLW 22
7 FES --------------- --------------- --------------- -------VLNRAVPK DKWVLNHEDLVLGEQ I-GRGNFGEVFSGRL 37
8 AF1 --------------- --------------- --------------- --------------- -------SEVMLSTR I-GSGSFGTVYKGKW 22
9 SVK --------------- --------------- --------------- --------------- -------MGFTIHGA L-TPGSEGCVFDSSH 22
10 MOS --------------- --------------- --------------- --------------- -------EQVCLLQR L-GAGGFGSVYKATY 22
11 DGM DQLVLGRTLGSGAFG QVVEATAHGLSHSQA TMKVAVKMLKSTARS SEKQALMSELYGDLV DYLHRNKHTFLQRHS NKHCPPSAELYSNAL 90
Page 2.1
91 105 106 120 121 135 136 150 151 165 166 180
1 pat-SB XggggggggXfjXrX gggggXXXXXrXXXX ggggkXXXXXXXrgg XXcfXcgggggggXX XXXXXXXXXXrfXXg ggggXXXfXXXXrXX 101
2 APK METGN----HYAMKI LDKQKVVKLKQIEHT L--NEKRILQAVN-F PFLVKL-----EFSF KDNSNLYMVMEYVPG -GEMFSHLRRIGRFS 99
3 SKH RATRQ----PYAIKM IE-TKYREGREVCES ----ELRVLRRVR-H ANIIQL-----VEVF ETQERVYMVMELATG -GELFDRIIAKGSFT 96
4 EE1 PVEKTL---KYAVKK LKV-KFSGPKERNRL L--QEVSIQRALKGH DHIVEL-----MDSW EHGGFLYMQVELCEN -GSLDRFLEEQGQLS 100
5 D28 LRPGQG-QRVVALKK I---RLESEDEGVPS TAIREISLLKELKD- DNIVRLY----DIVH SDAHKLYLVFEFLDL --DLKRYMEGIPKDQ 101
6 GFR IPEGEKVKIPVAIKE LREATSPKANKEILD ----EAYVMASVD-N PHVCRL------LGI CLTSTVQLITQLMP- ---FGCLLDYVREHK 97
7 FES RADNT----LVAVKS C-RETLPPDIKAKFL ---QEAKILKQYS-H PNIVRL-----IGVC TQKQPIYIVMELVQ- ----GGDFLTFLRTE 108
8 AF1 HG-------DVAVKI LKV--VDPTPEQFQA -FRNEVAVLRKTRHV NILLFM-------GY MTKDNLAIVTQWCE- ----GSSLYKHLHVQ 90
9 SVK P--------DYPQRV I---VKAGWYTSTSH ----EARLLRRLD-H PAILPLL----DLHV VSGVTCLVLPKYQA- --DLYTYLSRRLNPL 89
10 MOS R------GVPVAIKQ VNKCTKNRLASRRSF --WAELNVARLRH-- DNIVRVVAASTRTPA GSNSLGTIIMEFGGN VTLHQVIYGAAGHPE 102
11 DGM P-----VGFSLPSHL -----NLTGESDGGY ---MDMSKDESIDY- VPMLDM-------KG DIKYADIESPSYMAP ---YDNYVPSAPERT 156
Page 3.1
181 195 196 210 211 225 226 240 241 255 256 270
1 pat-SB XXXXXXXgggggggg ggggXrfXXggggjf XdfXXXXfXeXDcXj XNfffgggXXXXXfX cXDFGXjgggggXXr gggggggggXXXXXX 191
2 APK EPHARFYA------- ----AQIVL----TF EYLHSLDLIYRDLKP ENLLI---DQQGYIQ VTDFGFAK----RVK G--RTW---TLCGTP 162
3 SKH ERDATRV-------- ----LQMVLD---GV RYLHALGITHRDLKP ENLLYYHPGTDSKII ITDFGLASA---RKK G--DDCLMKTTCGTP 166
4 EE1 RLDEFRV-------- ----WKILVEVALGL QFIHHKNYVHLDLKP ANVMI---TFEGTLK IGDFGMASV-WPVPR G-------MEREGDC 167
5 D28 PLGADIV-------- ----KKFMMQLCKGI AYCHSHRILHRDLKP QNLLI---NKDGNLK LGDFGLARAFGVPLR A------YTHEIVTL 170
6 GFR DNIGSQYL------- ----LNWCVQIAKGM NYLEDRRLVHRDLAA RNVLV---KTPQHVK ITDFGLAKLLGAEEK ----EYHAEGGKVPI 169
7 FES GARLRMKT------- ---LLQMVGDAAAGM EYLESKCCIHRDLAA RNCLV---TEKNVLK ISDFGMSR---EAAD G-IYAASGGLRQVPV 181
8 AF1 ETKFQMFQ------- ---LIDIARQTAQGM DYLHAKNIIHRDMKS NNIFL---HEGLTVK IGDFGLAT---VKSR W-SGSQQVEQPTGSV 163
9 SVK GRPQIAAV------- ---SRQLLS----AV DYIHRQGIIHRDIKT ENIFI---NTPEDIC LGDFGAA--CFVQGS --RSSPFPYGIAGTI 158
10 MOS GDAGEPHCRTGGQLS LGKCLKYSLDVVNGL LFLHSQSIVHLDLKP ANILI---SEQDVCK ISDFGCS---EKLED LLCFQTPSYPLGGTY 186
11 DGM YRATLINDSPVLSYT DLVGFSYQVA--NGM DFLASKNCVHRDLAA RNVLI---CEGKLVK ICDFGLA---RDIMR -DSNYISKGSTYLPL 237
Page 4.1
271 285 286 300 301 315 316 330 331 345 346 360
1 pat-SB XXXAXEXgggXXXXX frXXXDXdjXhfXXX ggggXXXXXXXXXrX XXggggggggXrXXX rjXXXXXggggggjg gggjgggr------- 274
2 APK EYLAPEI---ILSKG YNKAVDWWALGVLIY E--MAAGYPPFFADQ PIQ--I----YEKIV SGKVRFPSH---FS- ---SDL-KDLLRNLL 233
3 SKH EYIAPEV---LVRKP YTNSVDMWALGVIAY I--LLSGTMPFEDDN RTR--L----YRQIL RGKYSYSGEP--WPS --VSNLAKDFIDRLL 241
4 EE1 EYIAPEV---LANHL YDKPADIFSLGITVF ----EAAANIVLPDN GQS-------WQKLR SGDLSDAPR---LS- ---S---TDNGSSLT 233
5 D28 WYRAPEVL--LGGKQ YSTGVDTWSIGCIFA E--MCNRKPIFSGDS EID--QIFKIFRVLG TPNEAIWPDIVYLPD FKPS-FPQWRRKDLS 253
6 GFR KWMALES---ILHRI YTHQSDVWSYGVTVW ---ELMTFGSKPYDG IP----ASEISSILE KGERLPQP-----PI --CTI--DVYMIMVK 240
7 FES KWTAPEA---LNYGR YSSESDVWSFGILLW E--TFSLGASPYPNL SN-----QQTREFVE KGGRLPCP--ELCP- --DAV-FRLMEQCWA 255
8 AF1 LWMAPEVIRMQDNNP FSFQSDVYSYGIVLY E--LMTGELPYSRDQ II-----FMVGRGYA SPDLSKL--YKNCP- --KAM--KRLVADCV 239
9 SVK DTNAPEV---LAGDP YTTTVDIWSAGLVIF ETAVHNASLFSAPRG PKRGPCDSQITRIIR QAQVHVD----EFSP --HPE--SRLTSRYR 237
10 MOS THRAPEL---LKGEG VTPKADIYSFAITLW -QMTTKQAPYSGERQ HILYAVVAYDLRPSL SAAVFED------SL ---PG--QRLGDVIQ 261
11 DGM KWMAPES---IFNSL YTTLSDVWSFGILLW --EIFTLGGTPYPEL PM--------NDQFY NAIKRGY----RMAQ ---PA--HASDEIYE 305
Page 5.1
361 375 376 390 391 405 406 420 421 435 436 450
1 pat-SB --------------- --------------- --------------- -- 274
2 APK QVDLTKRFGNLKDGV NDIKNHK-------- --------------- -- 255
3 SKH TVDPGARMTALQALR HPWVVSM-------- --------------- -- 263
4 EE1 SSSRETPANSIIGQG GLDRVVEWMLSPEPR NRPTIDQILATDEVC WV 280
5 D28 QVVPSLDPRGIDLLD KLLAYDPINRISARR AAIHPYFQES----- -- 293
6 GFR CWMIDADSRPKFREL IIEFSKMAR------ --------------- -- 264
7 FES YEPGQRPSFSAIYQE L-------------- --------------- -- 271
8 AF1 KKVKEERPLFPQILS SIELLQH-------- --------------- -- 261
9 SVK SRAAGNNRPPYTRPA WTRYYKMDIDV---- --------------- -- 263
10 MOS RCWRPSAAQRPSARL LLVDLTSLKA----- --------------- -- 286
11 DGM IMQKCWEEKFETRPP FSQLVLLLERLLGEG YKKKY---------- -- 340
Maximal Linkage Alignment Data (Fasta format)
>pat-ML
--------------------------------------------------
------------------------------------jrgggXgggVXXgg
ggggggggXXXjXXXXgggXXXXXXXXgrgggrXrXXrXcXggggggggg
gggXXrgggggggfXggXXrfXgggXXXXXrXgggcgggggggggggggg
gXrXgXXXXXgggXXfXgggggjfXdfXXXXfXeXDcXjXNfffgggXXX
XXfXcXDFGXjgggggggXXggggXjgXgggggXgggggXXXXAXEXgcX
XXgggXfrXXXDXdjXhfgggggggggXcXXXXgggggXgXXXXdggggg
XXXXgXXXXgggggXjgggXXfggggXggggggggggggggggXgggggX
fXXrXggggggXR------------------------
>FES
------------------------------------------------VL
NRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRAD-NTL---VAVKS
C-----RETLPPDIKAK--FLQEAKILKQ-YSHPNIVRLIGVCT------
---QKQ----P--IYI-VMELVQ--GGDFLTF---L--------------
-RTEGARLRMKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLV---TEK
NVLKISDFGMSR-----EAADGIYAASG-----GLRQVPVKWTAPEA-LN
YG---RYSSESDVWSFGI---------LLWETF-----SLGASPY-----
PNLS-NQQTREFVEKG---GRL----PC-----------PELCPDAVF-R
LMEQCWAYEPGQRPSFSAIYQEL--------------
>GFR
--------------------------------------------------
-------------TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKE
L-----REATSPKANKE--ILDEAYVMAS-VDNPHVCRLLGIC-------
---LTS----T--VQL-ITQLMP--FGCLLDY---V--------------
-REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV---KTP
QHVKITDFGLAKL---LGAEEKEYHAEG-----G--KVPIKWMALES-IL
HR---IYTHQSDVWSYGV---------TVWELM-----TFGSKPY-----
DGIP-ASEISSILEKG---ERL----PQ-----------PPICTIDVY-M
IMVKCWMIDADSRPKFRELIIEFSKMAR---------
>DGM
DQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQA
LMSELYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNA--LP--VGF--
--------SLPSHLNLT--GESDGGYM-D-MSKDESIDYVPMLDMKGDIK
YADIES----PSYMAP-YDNYVP--SAPERTYRATL--------------
-INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLI---CEG
KLVKICDFGLAR----DIMRDSNYISKG-----STY-LPLKWMAPES-IF
NS---LYTTLSDVWSFGI---------LLWEIF-----TLGGTPY-----
PELPMNDQFYNAIKRG---YRM----AQ-----------PAHASDEIY-E
IMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKY--
>AF1
--------------------------------------------------
-----------------SEVMLSTRIGSGSFGTVYKGK---WHGDVAVKI
L-----KVVDPTPEQFQ--AFRNEVAVLR---KTRHVNILLFM-------
-GYMTK-----DNLA-IVTQWCE--GSSLYKH---L--------------
HVQE-TKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL---HEG
LTVKIGDFGLATVKSRWSGSQQVEQP-T-----G----SVLWMAPEV-IR
MQDNNPFSFQSDVYSYGI---------VLYELM-----T-GELPYS--RD
QIIFMVGRGYASPDLS---KLY----KN-----------CPKAMKRLVAD
CVKKVK----EERPLFPQILSSIELLQH---------
>MOS
--------------------------------------------------
-----------------EQVCLLQRLGAGGFGSVYKAT---YRG-VPVAI
K-----QVNKCTKNRLA--SRRSFWAELN-VARLRHDNIVRVV-------
-AASTRTPAGSNSLGTIIMEFGG--NVTLHQV---IYGAAGHPEGDAGEP
HCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILI---SEQ
DVCKISDFGCSEKLEDLLCFQTPSYPLG-----G----TYTHRAPEL-LK
GE---GVTPKADIYSFAI---------TLWQMT-----T-KQAPYSGERQ
HILYAVVAYDLRPSLS---AAV----FE-----------DSLPGQRL-GD
VIQRC------WRPSAAQRPSARLLLVDLTSLKA---
>APK
--------------------------------------------------
------------------------DQFERIKTL-GTGS---FG-RVMLVK
H---METGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF--PFLVKL
EFSFKD---NSN-LYM-VMEYVP--GGEMFSH---LR------------R
IGRFSEPHARFYAAQIVL----TFEYLHSLDLIYRDLKPENLLI---DQQ
GYIQVTDFGFAK------RV----KGRTW---TLCGT--PEYLAPEI-IL
SK---GYNKAVDWWALGV------LIYEMAAGYPPFFADQPIQIY---EK
IVSGKVRFPSH---FS---SDL----K----------------DL-LRNL
LQVDL-----TKRFGNLKDGVNDIKNHK---------
>SKH
--------------------------------------------------
-------------------------AKYDIKALIGRGS---FS-RVVRVE
H---RATRQPYAIKMIE-TKYREGREVCES--ELRVLRRVRH--ANIIQL
VEVFET---QER-VYM-VMELAT--GGELFDR---II------------A
KGSFTERDATRV-LQMVLD---GVRYLHALGITHRDLKPENLLYYHPGTD
SKIIITDFGLAS-----ARK----KGDDCLMKTTCGT--PEYIAPEV-LV
RK---PYTNSVDMWALGV------IAYILLSGTMPFEDDNRTRLY---RQ
ILRGKYSYSGE--PWPS-VSNLA---K----------------DF-IDRL
LTVDP-----GARMTALQALRHPWVVSM---------
>D28
--------------------------------------------------
------------------------ANYKRLEKV-GEGT---YG-VVYKAL
DLRPGQGQRVVALKKIRL-ESEDEGVPSTAIREISLLKELK-D-DNIVRL
YDIVHS---DAHKLYL-VFEFL---DLDLKRY---ME------------G
IPKDQPLGADIV-KKFMMQLCKGIAYCHSHRILHRDLKPQNLLI---NKD
GNLKLGDFGLAR------AFGVPLRAYT----HEIVT--LWYRAPEVLLG
GK---QYSTGVDTWSIGCIFAEMCNRKPIFSGDSEI--DQIFKIF---RV
LGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPR-GID-LLDKL
LAYDP-----INRISARRAAIHPYFQES---------
>EE1
--------------------------------------------------
------------------------TRFRNVTLL-GSGE---FS-EVFQVE
D--PVEKTLKYAVKKLKV-KFSGPKERNRLLQEVSIQRALKGH-DHIVEL
MDSWEH---GGF-LYM-QVELCE--NGSLDRF---LE------------E
QGQLSRLDEFRV-WKILVEVALGLQFIHHKNYVHLDLKPANVMI---TFE
GTLKIGDFGMAS------VWPVP-RGME----RE-GD--CEYIAPEV-LA
NH---LYDKPADIFSLGI---------TVFEAAANIVLPDNGQSW---QK
LRSGDLSDAPR-LSSTDNGSSLTSSSRETPAN---SIIGQGGLDRVVEWM
LSPEP-----RNRPTIDQILATDEVCWV---------
>SVK
--------------------------------------------------
-------------------------MGFTIHGALTPGS---EG-CVFDSS
H-------PDYPQRVI--VKAGWYTSTSH---EARLLRRLDHP-AILPLL
DLHVVS---GVT-CLV-LPKYQADLYTYLSRR---LN------------P
LGRPQIAAVS---RQLL----SAVDYIHRQGIIHRDIKTENIFI---NTP
EDICLGDFGAA-------CFVQGSRSSPFPYG-IAGT--IDTNAPEV-LA
GD---PYTTTVDIWSAGL---------VIFETA-----VHNASLF---SA
PRGPKRGPC-----DSQ-ITRI---IR-----QAQVHVDEFSPHP--ESR
LTSRY-----RSRAAGNNRPPYTRPAWTRYYKMDIDV
Sequential Branching Alignment Data (Fasta format)
>pat-SB
--------------------------------------------------
-----------------------------jXXjXcfXXXXXggggggggX
fjXrXgggggXXXXXrXXXXggggkXXXXXXXrggXXcfXcgggggggXX
XXXXXXXXXXrfXXgggggXXXfXXXXrXXXXXXXXXggggggggggggX
rfXXggggjfXdfXXXXfXeXDcXjXNfffgggXXXXXfXcXDFGXjggg
ggXXrgggggggggXXXXXXXXXAXEXgggXXXXXfrXXXDXdjXhfXXX
ggggXXXXXXXXXrXXXggggggggXrXXXrjXXXXXggggggjggggjg
ggr-----------------------------------------------
-------
>APK
--------------------------------------------------
-----------------DQFERIKTL-GTGSFGRVMLVKHMETGN----H
YAMKILDKQKVVKLKQIEHTL--NEKRILQAVN-FPFLVKL-----EFSF
KDNSNLYMVMEYVPG-GEMFSHLRRIGRFSEPHARFYA-----------A
QIVL----TFEYLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAK--
--RVKG--RTW---TLCGTPEYLAPEI---ILSKGYNKAVDWWALGVLIY
E--MAAGYPPFFADQPIQ--I----YEKIVSGKVRFPSH---FS----SD
L-KDLLRNLLQVDLTKRFGNLKDGVNDIKNHK------------------
-------
>SKH
--------------------------------------------------
------------------AKYDIKALIGRGSFSRVVRVEHRATRQ----P
YAIKMIE-TKYREGREVCES----ELRVLRRVR-HANIIQL-----VEVF
ETQERVYMVMELATG-GELFDRIIAKGSFTERDATRV------------L
QMVLD---GVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASA-
--RKKG--DDCLMKTTCGTPEYIAPEV---LVRKPYTNSVDMWALGVIAY
I--LLSGTMPFEDDNRTR--L----YRQILRGKYSYSGEP--WPS--VSN
LAKDFIDRLLTVDPGARMTALQALRHPWVVSM------------------
-------
>EE1
--------------------------------------------------
-----------------TRFRNVTLL-GSGEFSEVFQVEDPVEKTL---K
YAVKKLKV-KFSGPKERNRLL--QEVSIQRALKGHDHIVEL-----MDSW
EHGGFLYMQVELCEN-GSLDRFLEEQGQLSRLDEFRV------------W
KILVEVALGLQFIHHKNYVHLDLKPANVMI---TFEGTLKIGDFGMASV-
WPVPRG-------MEREGDCEYIAPEV---LANHLYDKPADIFSLGITVF
----EAAANIVLPDNGQS-------WQKLRSGDLSDAPR---LS----S-
--TDNGSSLTSSSRETPANSIIGQGGLDRVVEWMLSPEPRNRPTIDQILA
TDEVCWV
>D28
--------------------------------------------------
-----------------ANYKRLEKV-GEGTYGVVYKALDLRPGQG-QRV
VALKKI---RLESEDEGVPSTAIREISLLKELKD-DNIVRLY----DIVH
SDAHKLYLVFEFLDL--DLKRYMEGIPKDQPLGADIV------------K
KFMMQLCKGIAYCHSHRILHRDLKPQNLLI---NKDGNLKLGDFGLARAF
GVPLRA------YTHEIVTLWYRAPEVL--LGGKQYSTGVDTWSIGCIFA
E--MCNRKPIFSGDSEID--QIFKIFRVLGTPNEAIWPDIVYLPDFKPS-
FPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES
-------
>GFR
--------------------------------------------------
-----------------TEFKKIKVL-GSGAFGTVYKGLWIPEGEKVKIP
VAIKELREATSPKANKEILD----EAYVMASVD-NPHVCRL------LGI
CLTSTVQLITQLMP----FGCLLDYVREHKDNIGSQYL-----------L
NWCVQIAKGMNYLEDRRLVHRDLAARNVLV---KTPQHVKITDFGLAKLL
GAEEK----EYHAEGGKVPIKWMALES---ILHRIYTHQSDVWSYGVTVW
---ELMTFGSKPYDGIP----ASEISSILEKGERLPQP-----PI--CTI
--DVYMIMVKCWMIDADSRPKFRELIIEFSKMAR----------------
-------
>FES
--------------------------------------------------
--VLNRAVPKDKWVLNHEDLVLGEQI-GRGNFGEVFSGRLRADNT----L
VAVKSC-RETLPPDIKAKFL---QEAKILKQYS-HPNIVRL-----IGVC
TQKQPIYIVMELVQ-----GGDFLTFLRTEGARLRMKT----------LL
QMVGDAAAGMEYLESKCCIHRDLAARNCLV---TEKNVLKISDFGMSR--
-EAADG-IYAASGGLRQVPVKWTAPEA---LNYGRYSSESDVWSFGILLW
E--TFSLGASPYPNLSN-----QQTREFVEKGGRLPCP--ELCP---DAV
-FRLMEQCWAYEPGQRPSFSAIYQEL------------------------
-------
>AF1
--------------------------------------------------
-----------------SEVMLSTRI-GSGSFGTVYKGKWHG-------D
VAVKILKV--VDPTPEQFQA-FRNEVAVLRKTRHVNILLFM-------GY
MTKDNLAIVTQWCE-----GSSLYKHLHVQETKFQMFQ----------LI
DIARQTAQGMDYLHAKNIIHRDMKSNNIFL---HEGLTVKIGDFGLAT--
-VKSRW-SGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLY
E--LMTGELPYSRDQII-----FMVGRGYASPDLSKL--YKNCP---KAM
--KRLVADCVKKVKEERPLFPQILSSIELLQH------------------
-------
>SVK
--------------------------------------------------
-----------------MGFTIHGAL-TPGSEGCVFDSSHP--------D
YPQRVI---VKAGWYTSTSH----EARLLRRLD-HPAILPLL----DLHV
VSGVTCLVLPKYQA---DLYTYLSRRLNPLGRPQIAAV----------SR
QLLS----AVDYIHRQGIIHRDIKTENIFI---NTPEDICLGDFGAA--C
FVQGS--RSSPFPYGIAGTIDTNAPEV---LAGDPYTTTVDIWSAGLVIF
ETAVHNASLFSAPRGPKRGPCDSQITRIIRQAQVHVD----EFSP--HPE
--SRLTSRYRSRAAGNNRPPYTRPAWTRYYKMDIDV--------------
-------
>MOS
--------------------------------------------------
-----------------EQVCLLQRL-GAGGFGSVYKATYR------GVP
VAIKQVNKCTKNRLASRRSF--WAELNVARLRH--DNIVRVVAASTRTPA
GSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLSLGKCL
KYSLDVVNGLLFLHSQSIVHLDLKPANILI---SEQDVCKISDFGCS---
EKLEDLLCFQTPSYPLGGTYTHRAPEL---LKGEGVTPKADIYSFAITLW
-QMTTKQAPYSGERQHILYAVVAYDLRPSLSAAVFED------SL---PG
--QRLGDVIQRCWRPSAAQRPSARLLLVDLTSLKA---------------
-------
>DGM
DQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQA
LMSELYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNALP-----VGFS
LPSHL-----NLTGESDGGY---MDMSKDESIDY-VPMLDM-------KG
DIKYADIESPSYMAP---YDNYVPSAPERTYRATLINDSPVLSYTDLVGF
SYQVA--NGMDFLASKNCVHRDLAARNVLI---CEGKLVKICDFGLA---
RDIMR-DSNYISKGSTYLPLKWMAPES---IFNSLYTTLSDVWSFGILLW
--EIFTLGGTPYPELPM--------NDQFYNAIKRGY----RMAQ---PA
--HASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKY-----
-------
Kim C. Worley, Human Genome Center, Baylor College of Medicine
Please send help queries to sl-help@dot.imgen.bcm.tmc.edu