Weight factors: normalized score[1][2] = -1, wf[1][2] = 1.000 normalized score[1][3] = -1, wf[1][3] = 1.000 normalized score[1][4] = -1, wf[1][4] = 1.000 normalized score[1][5] = -1, wf[1][5] = 1.000 normalized score[1][6] = -1, wf[1][6] = 1.000 normalized score[1][7] = -1, wf[1][7] = 1.000 normalized score[1][8] = -1, wf[1][8] = 1.000 normalized score[1][9] = -1, wf[1][9] = 1.000 normalized score[1][10] = -1, wf[1][10] = 1.000 normalized score[2][3] = -1, wf[2][3] = 1.000 normalized score[2][4] = -1, wf[2][4] = 1.000 normalized score[2][5] = -1, wf[2][5] = 1.000 normalized score[2][6] = -1, wf[2][6] = 1.000 normalized score[2][7] = -1, wf[2][7] = 1.000 normalized score[2][8] = -1, wf[2][8] = 1.000 normalized score[2][9] = -1, wf[2][9] = 1.000 normalized score[2][10] = -1, wf[2][10] = 1.000 normalized score[3][4] = -1, wf[3][4] = 1.000 normalized score[3][5] = -1, wf[3][5] = 1.000 normalized score[3][6] = -1, wf[3][6] = 1.000 normalized score[3][7] = -1, wf[3][7] = 1.000 normalized score[3][8] = -1, wf[3][8] = 1.000 normalized score[3][9] = -1, wf[3][9] = 1.000 normalized score[3][10] = -1, wf[3][10] = 1.000 normalized score[4][5] = -1, wf[4][5] = 1.000 normalized score[4][6] = -1, wf[4][6] = 1.000 normalized score[4][7] = -1, wf[4][7] = 1.000 normalized score[4][8] = -1, wf[4][8] = 1.000 normalized score[4][9] = -1, wf[4][9] = 1.000 normalized score[4][10] = -1, wf[4][10] = 1.000 normalized score[5][6] = -1, wf[5][6] = 1.000 normalized score[5][7] = -1, wf[5][7] = 1.000 normalized score[5][8] = -1, wf[5][8] = 1.000 normalized score[5][9] = -1, wf[5][9] = 1.000 normalized score[5][10] = -1, wf[5][10] = 1.000 normalized score[6][7] = -1, wf[6][7] = 1.000 normalized score[6][8] = -1, wf[6][8] = 1.000 normalized score[6][9] = -1, wf[6][9] = 1.000 normalized score[6][10] = -1, wf[6][10] = 1.000 normalized score[7][8] = -1, wf[7][8] = 1.000 normalized score[7][9] = -1, wf[7][9] = 1.000 normalized score[7][10] = -1, wf[7][10] = 1.000 normalized score[8][9] = -1, wf[8][9] = 1.000 normalized score[8][10] = -1, wf[8][10] = 1.000 normalized score[9][10] = -1, wf[9][10] = 1.000 DC Alignment: 1 _D28_____CD28__S._CEREVISIAE_CELL_CYCLE_CONTROL_PROTEIN_KINASE 2 _SKH___SKH__HELA_MYSTERY_PUTATIVE_PROTEIN_KINASE 3 _APK___CAPK__BOVINE_CARDIAC_MUSCLE_CYCLIC_AMP-DEPENDENT_(ALPHA) 4 _EE1___WEE1__S._POMBE_MITOTIC_INHIBITOR 5 _GFR___EGFR__HUMAN_EPIDERMAL_GROWTH_FACTOR_RECEPTOR 6 _DGM__PDGF_RECEPTOR,_MOUSE_KINASE_REGION_ 7 _FES__THIS_IS_VFES_TYROSINE_KINASE_______ 8 _AF1___RAF1__HUMAN_C-RAF-1_ONCOGENE 9 _MOS___CMOS__HUMAN_C-MOS_ONCOGENE 10 _SVK___HSVK__HERPES_SIMPLEX_VIRUS_PUTATIVE_PROTEIN_KINASE 10 20 30 40 50 60 1 ---------------ANYKRLEKVGEGTYGVVYKAL----DLRPGQG-QRVVALKKIR-- 38 2 ---------------AKYDIKALIGRGSFSRVVRVE----H--RAT--RQPYAIKMI--- 34 3 ---------------DQFERIKTLGTGSFGRVMLVK----H--MET--GNHYAMKILDKQ 37 4 ---------------TRFRNVTLLGSGEFSEVFQVE----D--PVEK-TLKYAVKKLKV- 37 5 ---------------TEFKKIKVLGSGAFGTVYKGL----WIPEGEKVKIPVAIKELR-- 39 6 ---------------DQLVLGRTLGSGAFGQVVEATAHGLS--HSQA-TMKVAVKMLK-- 40 7 VLNRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGR----L--RAD--NTLVAVKSCR-- 50 8 ---------------SEVMLSTRIGSGSFGTVYKGK----W--HG---DVAVKILKV--- 33 9 ---------------EQVCLLQRLGAGGFGSVYKAT----Y--R----GVPVAIKQVN-- 33 10 ---------------MGFTIHGALTPGSEGCVFDSS----H--P----DYPQRV-IV--- 31 70 80 90 100 110 120 1 LESEDEGVPSTAIRE-----ISL-LKELK-DDNI-----------VRLYDIVHSD----- 75 2 ETKYREGR-EVCESE-----LRV-LRRVR-HANI-----------IQLVE-VFET----- 69 3 KVVKLKQI-EHTLNE-----KRI-LQAVN-FPFL-----------VKLEF-SFKD----- 72 4 KFSGPKER-NRLLQE-----VSI-QRALKGHDHI-----------VELMD-SWEH----- 73 5 EATSPKAN-KEILDE-----AYV-MASVD-NPHV-----------CRLLG-ICL------ 73 6 STARSSEK-QALMSELYGDLVDY-LHRNK-HTFLQRHSNKHCPPSAELYS-NALPVGFSL 96 7 ETLPPDIK-AKFLQE-----AKI-LKQYS-HPNI-----------VRLIG-VCTQ----- 85 8 VDPTPEQF-QAFRNE-----VAV-LRKTR-HVNI-----------LLFMG-YMT------ 67 9 KCTKNRLA-SRRSFW-----AELNVARLR-HDNI-----------VRVVA-ASTRTP--- 71 10 KAGW---Y-TSTSHE-----ARL-LRRLD-HPAI-----------LPLLD-LHVV----- 63 130 140 150 160 170 180 1 ------AHKL---YL------VFEFLD-LDLKRYM-----------------EGIP---- 98 2 ------QERV---YM------VMELATGGELFDRI------------------I------ 90 3 ------NSNL---YM------VMEYVPGGEMFSHL------------------R------ 93 4 ------GGFL---YM------QVELCENGSLDRFL-----------------EEQG---- 97 5 ------TSTV---QL------ITQLMPFGCLLDYV-----------------RE------ 95 6 PSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERT 156 7 ------KQPI---YI------VMELVQGGDFLTFL-----------------RT------ 107 8 ------KDNL---AI------VTQWCEGSSLYKHL-----------------HV------ 89 9 ------AGSN---SLGTI---IMEFGGNVTLHQVI-YGAAGHPEGD------AGEPHCR- 111 10 ------SGVT---CL------VLPKYQ-ADLYTYL-----------------SR------ 84 190 200 210 220 230 240 1 -KDQPLGADIVKK------FMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGN---LKLG 148 2 -AKGSFTERDATR------VLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIIT 143 3 -RIGRFSEPHARF------YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY---IQVT 143 4 -QLSRLDEFRVWK------ILVEVALGLQFIHHKNYVHLDLKPANVMITFEGT---LKIG 147 5 -HKDNIGSQYLLN------WCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH---VKIT 145 6 YRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKL---VKIC 213 7 -EGARLRMKTLLQ------MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNV---LKIS 157 8 -QETKFQMFQLID------IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLT---VKIG 139 9 -TGGQLSLGKCLK------YSLDVVNGLLFLHSQSIVHLDLKPANILISEQDV---CKIS 161 10 -RLNPLGRPQIAA------VSRQLLSAVDYIHRQGIIHRDIKTENIFINTPED---ICLG 134 250 260 270 280 290 300 1 DFGLARAFGVPLRAYTHE-I---VTLWYRAPEVLL--GGKQYSTGVDTWSIGCIFAEMCN 202 2 DFGLASARKKGDDCLMKTTC---GTPEYIAPEVLV---RKPYTNSVDMWALGVIAYILLS 197 3 DFGFAK-RVKGRTWTL---C---GTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEMAA 193 4 DFGMASVWPVPRGMER---E---GDCEYIAPEVLA---NHLYDKPADIFSLGITVFEAAA 198 5 DFGLAKLLGAEEKEYHAE-GGK-VPIKWMALESIL---HRIYTHQSDVWSYGVTVWELMT 200 6 DFGLARDIMRDSNYISKG-STY-LPLKWMAPESIF---NSLYTTLSDVWSFGILLWEIFT 268 7 DFGMSREAADGIYAASGG-LRQ-VPVKWTAPEALN---YGRYSSESDVWSFGILLWETFS 212 8 DFGLATVKSRWSGSQQVE-QPT-GSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT 197 9 DFGCSEKLEDLLCFQTPS-YPLGGTYTHRAPELLK---GEGVTPKADIYSFAITLWQMTT 217 10 DFGAACFVQGSRSSPFPY-GIA-GTIDTNAPEVLA---GDPYTTTVDIWSAGLVIFETAV 189 310 320 330 340 350 360 1 RKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFK--PSFPQWRRKDLSQVVPSLD 260 2 ------GTMPFEDD--------N-----RTRLYRQILRG---KYSYSGEPW-----PSVS 230 3 ------GYPPFFAD--------Q-----PIQIYEKIVSG---KVRFP---------SHFS 222 4 NIVLPDNGQSWQKL--------RSGDLSDAPRLSSTDNG--SSLTSSSRETPAN--SIIG 246 5 F-----GSKPYDGI--------P-----ASEISSILEKG--ERLPQP---------PICT 231 6 L-----GGTPYPEL--------PM----NDQFYNAIKRG--YRMAQP---------AHAS 300 7 L-----GASPYPNL--------S-----NQQTREFVEKG--GRLPCP---------ELCP 243 8 ------GELPYSRD--------Q-----IIFMVGRGYAS--PDLSKLY--------KNCP 228 9 ------KQAPYSGE--------R-----QHILYAVVAYDLRPSLSAAVFED-----SLPG 253 10 H-----NASLFSAP------RGPKRGP-CDSQITRIIRQ--AQVHVD---------EFSP 226 370 380 390 400 1 PR-GIDLLDKL-LAYDPINRISARRAAIHPYFQES------- 293 2 NL-AKDFIDRL-LTVDPGARMTALQALRHPWVVSM------- 263 3 SD-LKDLLRNL-LQVDLTKRFGNLKDGVNDIKNHK------- 255 4 QGGLDRVVEWM-LSPEPRNRPTIDQILATDEVCWV------- 280 5 ID-VYMIMVKC-WMIDADSRPKFRELIIEFSKMAR------- 264 6 DE-IYEIMQKC-WEEKFETRPPFSQLVLLLERLLGEGYKKKY 340 7 DA-VFRLMEQC-WAYEPGQRPS-----FSAIYQEL------- 271 8 KA-MKRLVADC-VKKVKEERPLFPQILSSIELLQH------- 261 9 QR-LGDVIQRC-WRPSAAQRPSARLLLVDLTSLKA------- 286 10 HP-ESRLTSRYRSRAAGNNRPPYTRPAWTRYYKMDIDV---- 263 Sequences: ../tmp/kin10.fasta Costfile: cost/blosum62, free shift L = 30, W = 0, weights off Alignment cost: 140913 Elapsed CPU time: 11.46 sec.